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PMID: 17715978 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.

The Journal of organic chemistry ·Vol. 72 ·No. 19 ·2007-09-14 ·Pages 7343-51

Lane AL, Stout EP, Hay ME, Prusak AC, Hardcastle K, Fairchild CR, Franzblau SG, Le Roch K, Prudhomme J, Aalbersberg W, Kubanek J

Abstract

Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.

MeSH Terms
Animals Benzoates/chemistry,isolation & purification,pharmacology Crystallography, X-Ray Diterpenes/chemistry,isolation & purification,pharmacology Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Phenols/chemistry,isolation & purification,pharmacology Rhodophyta/chemistry
Chemicals
Benzoates Diterpenes Phenols
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Lane Amy L
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Stout Elizabeth P
Hay Mark E
Prusak Anne C
Hardcastle Kenneth
Fairchild Craig R
Franzblau Scott G
Le Roch Karine
Prudhomme Jacques
Aalbersberg William
Kubanek Julia
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Article Info
Journal
The Journal of organic chemistry
Abbr.
J Org Chem
ISSN
0022-3263
DOI
10.1021/jo071210y
Published
2007-09-14
Epub
2007-00-23
Pages
7343-51
Language
English
Region
United States
NLM ID
2985193R
PMCID
PMC3374858
Subset
IM
Grants
FIC NIH HHS · U01 TW007401 · United States
FIC NIH HHS · U19 TW007401 · United States
FIC NIH HHS · 1U01 TW 007401-01 · United States
External Links
PubMed source DOI: 10.1021/jo071210y PMC Full Text View journal details
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