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PMID: 8792625 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa.

Journal of natural products ·Vol. 59 ·No. 8 ·1996-08-00 ·Pages 786-8

Prinsep MR, Thomson RA, West ML, Wylie BL

Abstract

A new diterpenoid, tolypodiol (1), has been isolated from the terrestrial cyanobacterium Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The monoacetate derivative 2 was prepared. Tolypodiol (1) and its monoacetate derivative 2 show potent antiinflammatory activity in the mouse ear edema assay.

MeSH Terms

Acetylation Animals Anti-Inflammatory Agents/chemistry,isolation & purification,therapeutic use Culture Media Cyanobacteria/metabolism Disease Models, Animal Diterpenes/chemistry,isolation & purification,therapeutic use Ear Diseases/chemically induced,drug therapy Edema/chemically induced,drug therapy Freeze Drying Lethal Dose 50 Magnetic Resonance Spectroscopy Mice Tetradecanoylphorbol Acetate/administration & dosage,toxicity

Chemicals

Anti-Inflammatory Agents Culture Media Diterpenes tolypodiol Tetradecanoylphorbol Acetate

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Prinsep M R

Department of Chemistry, University of Waikato, Hamilton, New Zealand. michele@waikato.ac.nz

Thomson R A

West M L

Wylie B L

Article Info

Journal

Journal of natural products

Abbr.

J Nat Prod

ISSN

0163-3864

DOI

10.1021/np9602574

michele@waikato.ac.nz

Published

1996-08-00

Pages

786-8

Language

English

Region

United States

NLM ID

7906882

Subset

Grants

NCI NIH HHS · CA 12623 · United States

External Links

PubMed source DOI: 10.1021/np9602574 View journal details

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Tolypodiol, an antiinflammatory diterpenoid from the cyanobacterium Tolypothrix nodosa.

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