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PMID: 17712414 Published · epublish English Journal Article Research Support, N.I.H., Extramural

The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists.

PloS one ·Vol. 2 ·No. 8 ·2007-08-22 ·Pages e766

Heinicke S, Livstone MS, Lu C, Oughtred R, Kang F, Angiuoli SV, White O, Botstein D, Dolinski K

Abstract

Many biological databases that provide comparative genomics information and tools are now available on the internet. While certainly quite useful, to our knowledge none of the existing databases combine results from multiple comparative genomics methods with manually curated information from the literature. Here we describe the Princeton Protein Orthology Database (P-POD, http://ortholog.princeton.edu), a user-friendly database system that allows users to find and visualize the phylogenetic relationships among predicted orthologs (based on the OrthoMCL method) to a query gene from any of eight eukaryotic organisms, and to see the orthologs in a wider evolutionary context (based on the Jaccard clustering method). In addition to the phylogenetic information, the database contains experimental results manually collected from the literature that can be compared to the computational analyses, as well as links to relevant human disease and gene information via the OMIM, model organism, and sequence databases. Our aim is for the P-POD resource to be extremely useful to typical experimental biologists wanting to learn more about the evolutionary context of their favorite genes. P-POD is based on the commonly used Generic Model Organism Database (GMOD) schema and can be downloaded in its entirety for installation on one's own system. Thus, bioinformaticians and software developers may also find P-POD useful because they can use the P-POD database infrastructure when developing their own comparative genomics resources and database tools.

MeSH Terms
Algorithms Animals Computational Biology/methods Databases, Protein Evolution, Molecular Genomics/methods Humans Internet Molecular Sequence Data Phylogeny Tubulin/classification,genetics User-Computer Interface
Chemicals
Tubulin
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Heinicke Sven
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Livstone Michael S
Lu Charles
Oughtred Rose
Kang Fan
Angiuoli Samuel V
White Owen
Botstein David
Dolinski Kara
References (115)
115 references, click to expand
  1. Hailey-Hailey disease as an orthodisease of PMR1 deficiency in Saccharomyces cerevisiae.
    FEBS Lett. 2005 Apr 11;579(10):2021-5 PMID: 15811312
  2. Plasmodium falciparum: glycosylation status of Plasmodium falciparum circumsporozoite protein expressed in the baculovirus system.
    Exp Parasitol. 2002 May;101(1):64-8 PMID: 12243739
  3. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants.
    Yeast. 2001 Oct;18(14):1309-16 PMID: 11571755
  4. Reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants.
    Mol Gen Genet. 1996 Dec 13;253(3):334-41 PMID: 9003320
  5. Nucleotide sequence of Arabidopsis thaliana arginase expressed in yeast.
    Plant Physiol. 1995 Apr;107(4):1479-80 PMID: 7770544
  6. Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia.
    Hum Mol Genet. 1998 Sep;7(9):1411-5 PMID: 9700195
  7. Functional expression in yeast of the human secretory pathway Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease.
    J Biol Chem. 2002 Feb 22;277(8):6422-7 PMID: 11741891
  8. Functional analysis of human MutSalpha and MutSbeta complexes in yeast.
    Nucleic Acids Res. 1999 Feb 1;27(3):736-42 PMID: 9889267
  9. Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae.
    J Biol Chem. 2004 Jul 2;279(27):28807-16 PMID: 15117943
  10. A gain of superoxide dismutase (SOD) activity obtained with CCS, the copper metallochaperone for SOD1.
    J Biol Chem. 1999 Dec 24;274(52):36952-6 PMID: 10601249
  11. Domain fusion between SNF1-related kinase subunits during plant evolution.
    EMBO Rep. 2001 Jan;2(1):55-60 PMID: 11252725
  12. Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.
    Am J Hum Genet. 1995 Jan;56(1):131-41 PMID: 7825568
  13. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.
    Biochem J. 2004 Sep 1;382(Pt 2):519-26 PMID: 15153069
  14. Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase.
    Arch Biochem Biophys. 1999 Dec 15;372(2):300-8 PMID: 10600168
  15. Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis.
    J Biol Chem. 2000 Mar 3;275(9):6227-33 PMID: 10692417
  16. The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
    Nature. 1997 May 29;387(6632 Suppl):103-5 PMID: 9169875
  17. GeneMCL in microarray analysis.
    Comput Biol Chem. 2005 Oct;29(5):354-9 PMID: 16172020
  18. The C66W mutation in the deafness dystonia peptide 1 (DDP1) affects the formation of functional DDP1.TIM13 complexes in the mitochondrial intermembrane space.
    J Biol Chem. 2002 Jun 28;277(26):23287-93 PMID: 11956200
  19. OMIA (Online Mendelian Inheritance in Animals): an enhanced platform and integration into the Entrez search interface at NCBI.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D599-601 PMID: 16381939
  20. High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.
    Infect Immun. 2002 Aug;70(8):4471-6 PMID: 12117958
  21. Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase.
    J Biol Chem. 1996 Apr 19;271(16):9795-800 PMID: 8621661
  22. Expression of Hailey-Hailey disease mutations in yeast.
    J Invest Dermatol. 2004 Dec;123(6):1192-4 PMID: 15610533
  23. Cross-referencing eukaryotic genomes: TIGR Orthologous Gene Alignments (TOGA).
    Genome Res. 2002 Mar;12(3):493-502 PMID: 11875039
  24. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides.
    J Biol Chem. 1994 Apr 29;269(17):12908-17 PMID: 8175708
  25. OrthoMCL: identification of ortholog groups for eukaryotic genomes.
    Genome Res. 2003 Sep;13(9):2178-89 PMID: 12952885
  26. Copper-induced trafficking of the cU-ATPases: a key mechanism for copper homeostasis.
    Biometals. 2003 Mar;16(1):175-84 PMID: 12572677
  27. OrthoDisease: a database of human disease orthologs.
    Hum Mutat. 2004 Aug;24(2):112-9 PMID: 15241792
  28. COCO-CL: hierarchical clustering of homology relations based on evolutionary correlations.
    Bioinformatics. 2006 Apr 1;22(7):779-88 PMID: 16434444
  29. The COG database: an updated version includes eukaryotes.
    BMC Bioinformatics. 2003 Sep 11;4:41 PMID: 12969510
  30. Functional assessment of the carboxy-terminus of the Wilson disease copper-transporting ATPase, ATP7B.
    Genomics. 2004 Mar;83(3):473-81 PMID: 14962673
  31. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.
    BMC Mol Biol. 2005 May 13;6:12 PMID: 15892892
  32. The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells.
    EMBO J. 1995 Nov 15;14(22):5626-37 PMID: 8521820
  33. Functional complementation analysis of yeast bc1 mutants. A study of the mitochondrial import of heterologous and hybrid proteins.
    Eur J Biochem. 1999 Sep;264(3):825-32 PMID: 10491129
  34. OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D363-8 PMID: 16381887
  35. Functional identification of an Arabidopsis snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast.
    Plant J. 2000 Jul;23(1):115-22 PMID: 10929106
  36. Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death.
    Exp Gerontol. 2004 May;39(5):707-15 PMID: 15130665
  37. Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin.
    Proc Natl Acad Sci U S A. 1992 May 15;89(10):4466-70 PMID: 1533933
  38. Alpha-tubulin from early-diverging eukaryotic lineages and the evolution of the tubulin family.
    Mol Biol Evol. 1996 Dec;13(10):1297-305 PMID: 8952074
  39. A novel family of cys-rich membrane proteins mediates cadmium resistance in Arabidopsis.
    Plant Physiol. 2004 Jun;135(2):1027-39 PMID: 15181212
  40. Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik.
    Am J Hum Genet. 2004 Mar;74(3):472-81 PMID: 14973778
  41. The ACA4 gene of Arabidopsis encodes a vacuolar membrane calcium pump that improves salt tolerance in yeast.
    Plant Physiol. 2000 Dec;124(4):1814-27 PMID: 11115896
  42. Expression of heterologous phosphofructokinase genes in yeast.
    FEBS Lett. 1993 Aug 9;328(1-2):35-40 PMID: 8344431
  43. GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes.
    Bioinformatics. 2004 Dec 12;20(18):3710-5 PMID: 15297299
  44. A plant plasma membrane Ca2+ pump is required for normal pollen tube growth and fertilization.
    Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9502-7 PMID: 15197266
  45. Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO).
    Nucleic Acids Res. 2002 Jan 1;30(1):69-72 PMID: 11752257
  46. Functional analysis in Saccharomyces cerevisiae of naturally occurring amino acid substitutions in human dihydrolipoamide dehydrogenase.
    Hum Mol Genet. 1996 Oct;5(10):1643-8 PMID: 8894701
  47. Overexpression of human UDP-glucose pyrophosphorylase rescues galactose-1-phosphate uridyltransferase-deficient yeast.
    Biochem Biophys Res Commun. 2000 May 10;271(2):392-400 PMID: 10799308
  48. EMBL Nucleotide Sequence Database in 2006.
    Nucleic Acids Res. 2007 Jan;35(Database issue):D16-20 PMID: 17148479
  49. Identification and analysis of the Arabidopsis thaliana BSH gene, a member of the SNF5 gene family.
    Nucleic Acids Res. 1999 Jun 1;27(11):2393-9 PMID: 10325430
  50. Automatic clustering of orthologs and inparalogs shared by multiple proteomes.
    Bioinformatics. 2006 Jul 15;22(14):e9-15 PMID: 16873526
  51. Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast.
    Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33 PMID: 14567972
  52. The lamin B receptor of Drosophila melanogaster.
    J Cell Sci. 2004 Apr 15;117(Pt 10):2015-28 PMID: 15054108
  53. Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
    Hum Mol Genet. 2005 Feb 15;14 (4):555-63 PMID: 15649950
  54. Yeast lacking superoxide dismutase(s) show elevated levels of "free iron" as measured by whole cell electron paramagnetic resonance.
    J Biol Chem. 2000 Sep 22;275(38):29187-92 PMID: 10882731
  55. Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant.
    Histochem Cell Biol. 2001 Mar;115(3):189-94 PMID: 11326746
  56. The AtPPT1 gene encoding 4-hydroxybenzoate polyprenyl diphosphate transferase in ubiquinone biosynthesis is required for embryo development in Arabidopsis thaliana.
    Plant Mol Biol. 2004 Jul;55(4):567-77 PMID: 15604701
  57. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells.
    J Biol Chem. 1998 Apr 10;273(15):9249-54 PMID: 9535917
  58. YOGY: a web-based, integrated database to retrieve protein orthologs and associated Gene Ontology terms.
    Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W330-4 PMID: 16845020
  59. Human xeroderma pigmentosum group D gene encodes a DNA helicase.
    Nature. 1993 Oct 28;365(6449):852-5 PMID: 8413672
  60. A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis.
    EMBO J. 1996 May 1;15(9):2115-24 PMID: 8641277
  61. Caenorhabditis elegans cDNA for a Menkes/Wilson disease gene homologue and its function in a yeast CCC2 gene deletion mutant.
    J Biochem. 1997 Jun;121(6):1169-75 PMID: 9354393
  62. Molecular cloning of Drosophila gamma-glutamylcysteine synthetase by functional complementation of a yeast mutant.
    FEBS Lett. 2000 Feb 11;467(2-3):337-40 PMID: 10675565
  63. ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg.
    Hum Mol Genet. 2002 Sep 15;11(19):2331-9 PMID: 12217961
  64. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.
    J Biol Chem. 2001 Oct 5;276(40):37327-34 PMID: 11489896
  65. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
    Cell. 1990 Nov 16;63(4):851-9 PMID: 2121371
  66. Functional XPB/RAD25 redundancy in Arabidopsis genome: characterization of AtXPB2 and expression analysis.
    Gene. 2005 Jan 3;344:93-103 PMID: 15656976
  67. Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.
    Hum Mol Genet. 2000 Oct 12;9(17):2523-30 PMID: 11030757
  68. Database resources of the National Center for Biotechnology Information.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D173-80 PMID: 16381840
  69. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype.
    Nucleic Acids Res. 2001 Dec 15;29(24):4935-40 PMID: 11812822
  70. Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.
    Gene. 2003 Nov 27;320:137-44 PMID: 14597397
  71. Expression pattern of a nuclear encoded mitochondrial arginine-ornithine translocator gene from Arabidopsis.
    BMC Plant Biol. 2003 Jan 07;3:1 PMID: 12517306
  72. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.
    Cell. 1990 Nov 16;63(4):835-41 PMID: 2121369
  73. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.
    Science. 1992 Apr 10;256(5054):232-4 PMID: 1348873
  74. Inparanoid: a comprehensive database of eukaryotic orthologs.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D476-80 PMID: 15608241
  75. Assessing performance of orthology detection strategies applied to eukaryotic genomes.
    PLoS One. 2007 Apr 18;2(4):e383 PMID: 17440619
  76. Arabidopsis thaliana cDNA isolated by functional complementation shows homology to serine/threonine protein kinases.
    Biochim Biophys Acta. 1996 Mar 1;1305(3):125-9 PMID: 8597596
  77. GenBank.
    Nucleic Acids Res. 2007 Jan;35(Database issue):D21-5 PMID: 17202161
  78. BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast.
    Cancer Res. 2005 Jul 1;65(13):5520-2 PMID: 15994923
  79. A yeast model for the study of Batten disease.
    Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6915-8 PMID: 9618513
  80. Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts.
    Genes Cells. 1997 Oct;2(10 ):601-14 PMID: 9427282
  81. Effect of ATP binding cassette/multidrug resistance proteins on ATP efflux of Saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1997 Jan 3;230(1):22-6 PMID: 9020050
  82. Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutant.
    Gene. 2002 Aug 21;296(1-2):1-9 PMID: 12383497
  83. Glycosylphosphatidylinositol anchors represent the major carbohydrate modification in proteins of intraerythrocytic stage Plasmodium falciparum.
    J Biol Chem. 1997 Mar 7;272(10):6428-39 PMID: 9045667
  84. SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.
    Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):909-14 PMID: 9927667
  85. Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.
    J Biol Chem. 1999 Nov 26;274(48):33905-12 PMID: 10567352
  86. Long-lost relatives reappear: identification of new members of the tubulin superfamily.
    Curr Opin Microbiol. 2003 Dec;6(6):634-40 PMID: 14662361
  87. Belle is a Drosophila DEAD-box protein required for viability and in the germ line.
    Dev Biol. 2005 Jan 1;277(1):92-101 PMID: 15572142
  88. The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.
    Mol Biol Cell. 1999 Mar;10(3):665-76 PMID: 10069810
  89. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.
    Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8733-8 PMID: 9671747
  90. RNA polymerase IV directs silencing of endogenous DNA.
    Science. 2005 Apr 1;308(5718):118-20 PMID: 15692015
  91. Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL.
    Am J Hum Genet. 2004 Jul;75(1):146-50 PMID: 15148656
  92. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.
    Science. 2003 Dec 5;302(5651):1769-72 PMID: 14657499
  93. GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: identification and functional characterization of four novel mutations.
    J Inherit Metab Dis. 2004;27(4):455-63 PMID: 15303002
  94. Purification and functional reconstitution of the human Wilson copper ATPase, ATP7B.
    FEBS Lett. 2005 Jul 4;579(17):3589-95 PMID: 15963506
  95. An ABC-transporter of Arabidopsis thaliana has both glutathione-conjugate and chlorophyll catabolite transport activity.
    Plant J. 1998 Mar;13(6):773-80 PMID: 9681016
  96. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins.
    J Biol Chem. 2005 Apr 8;280(14):14097-104 PMID: 15668246
  97. Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation.
    Cell. 2005 Mar 11;120(5):613-22 PMID: 15766525
  98. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
    Mol Cell. 2004 Jul 2;15(1):95-105 PMID: 15225551
  99. Genetics of eukaryotic RNA polymerases I, II, and III.
    Microbiol Rev. 1993 Sep;57(3):703-24 PMID: 8246845
  100. Orthologs, paralogs, and evolutionary genomics.
    Annu Rev Genet. 2005;39:309-38 PMID: 16285863
  101. Hepatitis C virus core protein binds to a DEAD box RNA helicase.
    J Biol Chem. 1999 May 28;274(22):15751-6 PMID: 10336476
  102. ERS1 encodes a functional homologue of the human lysosomal cystine transporter.
    FEBS J. 2005 May;272(10):2497-511 PMID: 15885099
  103. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
    Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 PMID: 7984417
  104. Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes.
    Mol Cell Biol. 1994 Jan;14(1):815-21 PMID: 8264648
  105. Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I.
    Biochem Biophys Res Commun. 1999 Feb 16;255(2):521-7 PMID: 10049741
  106. Isolation of a tobacco cDNA encoding Sar1 GTPase and analysis of its dominant mutations in vesicular traffic using a yeast complementation system.
    Plant Cell Physiol. 1998 Jun;39(6):590-9 PMID: 9697342
  107. ECA1 complements yeast mutants defective in Ca2+ pumps and encodes an endoplasmic reticulum-type Ca2+-ATPase in Arabidopsis thaliana.
    Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8579-84 PMID: 9238019
  108. Overview and comparison of ortholog databases.
    Drug Discov Today Technol. 2006 Summer;3(2):137-43 PMID: 24980400
  109. Functional expression of the menkes disease protein reveals common biochemical mechanisms among the copper-transporting P-type ATPases.
    J Biol Chem. 1998 Feb 6;273(6):3765-70 PMID: 9452509
  110. Functional homology of mammalian and yeast RAS genes.
    Cell. 1985 Jan;40(1):19-26 PMID: 2981628
  111. Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants.
    J Biol Chem. 1999 Dec 17;274(51):36089-96 PMID: 10593891
  112. Lethality in yeast of trichothiodystrophy (TTD) mutations in the human xeroderma pigmentosum group D gene. Implications for transcriptional defect in TTD.
    J Biol Chem. 1995 Jul 28;270(30):17660-3 PMID: 7629061
  113. Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.
    Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7873-8 PMID: 9223280
  114. A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes.
    Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6577-80 PMID: 8341671
  115. Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.
    Hum Mol Genet. 2003 Aug 15;12(16):1995-2001 PMID: 12913070
Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0000766
Published
2007-08-22
Epub
2007-00-22
Pages
e766
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC1942082
Subset
IM
Grants
NIAID NIH HHS · N01AI40038 · United States
NIGMS NIH HHS · P50 GM071508 · United States
NHGRI NIH HHS · R01 HG003471 · United States
NHGRI NIH HHS · 5R01HG003471 · United States
External Links
PubMed source DOI: 10.1371/journal.pone.0000766 PMC Full Text View journal details
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