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PMID: 17575050 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.

Genes & development ·Vol. 21 ·No. 12 ·2007-06-15 ·Pages 1484-93

Palma K, Zhao Q, Cheng YT, Bi D, Monaghan J, Cheng W, Zhang Y, Li X

Abstract

Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity.

MeSH Terms
Animals Arabidopsis/genetics,immunology,metabolism Arabidopsis Proteins/genetics,immunology Carrier Proteins/genetics,immunology Genes, Plant Humans Immunity, Innate Mutation Nuclear Proteins/genetics,immunology Plant Proteins/genetics,immunology Plants/genetics,immunology,metabolism RNA Splicing Recombinant Proteins/genetics,immunology Two-Hybrid System Techniques
Chemicals
Arabidopsis Proteins Carrier Proteins Nuclear Proteins PRL1 protein, Arabidopsis Plant Proteins Recombinant Proteins SNC1 protein, Arabidopsis
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Palma Kristoffer
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Zhao Qingguo
Cheng Yu Ti
Bi Dongling
Monaghan Jacqueline
Cheng Wei
Zhang Yuelin
Li Xin
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1559607
Published
2007-06-15
Pages
1484-93
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC1891426
Subset
IM
External Links
PubMed source DOI: 10.1101/gad.1559607 PMC Full Text View journal details
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