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PMID: 17490627 Published · ppublish English Journal Article Review

Nitric oxide regulation of protein trafficking in the cardiovascular system.

Cardiovascular research ·Vol. 75 ·No. 2 ·2007-07-15 ·Pages 240-6

Lowenstein CJ

Abstract

Nitric oxide (NO) is a second messenger with diverse roles in the cardiovascular system, such as inhibiting thrombosis and limiting vascular inflammation. One mechanism by which NO modulates such disparate physiological processes is by regulating protein trafficking within cells. NO inhibits exocytosis of endothelial granules which would otherwise trigger inflammation. NO also blocks platelet secretion of granules that would otherwise activate thrombosis. NO decreases granule trafficking from the Golgi to the plasma membrane by targeting a key component of the exocytic machinery, N-ethylmaleimide sensitive factor (NSF). In contrast to its inhibitory effects on exocytosis, NO accelerates endocytosis. S-nitrosylation of dynamin increases its ability to hydrolyze GTP, assemble in oligomers around a nascent vesicle, and cleave the endocytic vesicle free from the plasma membrane. NO regulation of vesicle trafficking is a molecular mechanism that explains some of the cardiovascular effects of NO, and may be of broad physiological significance.

MeSH Terms
Animals Cardiovascular System/metabolism Dynamins/metabolism Endothelial Cells/metabolism Humans N-Ethylmaleimide-Sensitive Proteins/metabolism Nitric Oxide/metabolism Nitrosation Protein Transport/physiology Thrombosis/metabolism
Chemicals
Nitric Oxide N-Ethylmaleimide-Sensitive Proteins Dynamins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lowenstein Charles J
The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. clowenst@jhmi.edu
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Article Info
Journal
Cardiovascular research
Abbr.
Cardiovasc Res
ISSN
0008-6363
DOI
10.1016/j.cardiores.2007.03.024
Email
clowenst@jhmi.edu
Published
2007-07-15
Epub
2007-00-03
Pages
240-6
Language
English
Region
England
NLM ID
0077427
PMCID
PMC2213885
Subset
IM
Grants
NHLBI NIH HHS · P01 HL065608 · United States
NHLBI NIH HHS · R01 HL078635 · United States
NHLBI NIH HHS · P01 HL056091 · United States
NHLBI NIH HHS · P01 HL056091-100003 · United States
NHLBI NIH HHS · R01 HL078635-03 · United States
NHLBI NIH HHS · P01 HL065608-070007 · United States
NHLBI NIH HHS · R01 HL074061-04 · United States
NHLBI NIH HHS · R01 HL074061 · United States
External Links
PubMed source DOI: 10.1016/j.cardiores.2007.03.024 PMC Full Text View journal details
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