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PMID: 171018 Published · ppublish English Journal Article

An electrophysiological analysis of the effect of Ca ions on neuromuscular transmission in the mouse vas deferens.

British journal of pharmacology ·Vol. 55 ·No. 1 ·1975-09-00 ·Pages 97-104

Bennett MR, Florin T

Abstract

1 A study has been made of the effects of changing the external calcium concentration [Ca]0 and the external magnesium concentration [Mg]0 on the synaptic potential due to noradrenaline release. 2 When [Ca]0 was varied in the range 0.7 to 1.8 mM, the synaptic potential increased as about the second power of [Ca]0. 3 Increasing [Mg]0 depressed the synaptic potential; however, variation of [Ca]0 in the presence of high [Mg]0 did not significantly change the power relationship between the synaptic potential and [Ca]0. 4 The facilitated increase in the synaptic potential during short trains of impulses at different frequencies was quantitatively predicted on the assumption that each impulse leaves residual Ca ions bound to release receptors in the nerve terminal.

MeSH Terms
Action Potentials/drug effects Animals Calcium/pharmacology Electric Stimulation In Vitro Techniques Kinetics Magnesium/pharmacology Male Mice Neuromuscular Junction/drug effects,physiology Norepinephrine/metabolism Synapses/physiology Synaptic Transmission/drug effects Vas Deferens/innervation,metabolism,physiology
Chemicals
Magnesium Calcium Norepinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bennett M R
Florin T
References (30)
30 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1975.tb07616.x
Published
1975-09-00
Pages
97-104
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1666704
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1975.tb07616.x PMC Full Text View journal details
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