The effect of calcium ions on the binomial statistic parameters which control acetylcholine release at synapses in striated muscle.

The Journal of physiology ·Vol. 247 ·No. 2 ·1975-05-00 ·Pages 429-46

Bennett MR, Florin T, Hall R

Abstract

A study has been made of the effects of changing [Ca]O and [Mg]O on the binomial statistic parameters p and n which control the average quantal content (m) of the synaptic potential due to acetylcholine release. 2. When [Ca]O was varied in the range 0-1 to 1-0 mM, p increased as the first power of [Ca]O whereas n increased as the third power of [Ca]O. 3. Increasing [Mg]O depressed both p and n, however variations of [Ca]O in the presence of high [Mg]O did not significantly change the power relationship between either p and [Ca]O or between n and [Ca]O. 4. The facilitated increase in m during a short train was due to an increase in n, whereas the post-tetanic increase in m during a tetanus was due to an increase in p. These results are considered in terms of the role of Ca ions in facilitation and post-tetanic potentiation.

MeSH Terms

Acetylcholine/metabolism Animals Calcium/pharmacology Electric Stimulation Electrophysiology In Vitro Techniques Magnesium/pharmacology Muscles/drug effects Neuromuscular Junction/drug effects,metabolism Rats Statistics as Topic Synapses/drug effects,physiology

Chemicals

Magnesium Acetylcholine Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bennett M R

Florin T

Hall R

References (28)

28 references, click to expand

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Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1975.sp010939

Published

1975-05-00

Pages

429-46

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1309477

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1975.sp010939 PMC Full Text View journal details

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The effect of calcium ions on the binomial statistic parameters which control acetylcholine release at synapses in striated muscle.

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