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PMID: 17027697 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Assessment of genome and proteome profiles in cocaine abuse.

Progress in brain research ·Vol. 158 ·2006-00-00 ·Pages 173-95

Hemby SE

Abstract

Until recently, knowledge of the impact of abuse drugs on gene and protein expression in the brain was limited to less than 100 targets. With the advent of high-throughput genomic and proteomic techniques investigators are now able to evaluate changes across the entire genome and across thousands of proteins in defined brain regions and generate expression profiles of vulnerable neuroanatomical substrates in rodent and non-human primate drug abuse models and in human post-mortem brain tissue from drug abuse victims. The availability of gene and protein expression profiles will continue to expand our understanding of the short- and long-term consequences of drug addiction and other addictive disorders and may provide new approaches or new targets for pharmacotherapeutic intervention. This chapter will review gene expression data from rodent, non-human primate and human post-mortem studies of cocaine abuse and will provide a preliminary proteomic profile of human cocaine abuse and explore how these studies have advanced our understanding of addiction.

MeSH Terms
Animals Behavior, Addictive/genetics Cocaine-Related Disorders/genetics Gene Expression Gene Expression Profiling Genomics Humans Proteomics
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hemby Scott E
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. shemby@wfubmc.edu <shemby@wfubmc.edu>
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Article Info
Journal
Progress in brain research
Abbr.
Prog Brain Res
ISSN
0079-6123
DOI
10.1016/S0079-6123(06)58009-4
Email
shemby@wfubmc.edu
Published
2006-00-00
Pages
173-95
Language
English
Region
Netherlands
NLM ID
0376441
PMCID
PMC4048548
Subset
IM
Grants
NIDA NIH HHS · R01 DA013234 · United States
NIDA NIH HHS · R01 DA013772 · United States
NIDA NIH HHS · DA013234 · United States
NIDA NIH HHS · DA013772 · United States
External Links
PubMed source DOI: 10.1016/S0079-6123(06)58009-4 PMC Full Text View journal details
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