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PMID: 11122919 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Recent advances in the biology of addiction.

Current psychiatry reports ·Vol. 1 ·No. 2 ·1999-12-00 ·Pages 159-65

Hemby SE

Abstract

Recent research into the biologic basis of drug addiction continues to offer considerable promise for understanding how neurochemistry, pharmacology, and molecular biology relate to the reinforcing effects of abused drugs. One area of research is the development and pharmacologic and neurochemical characterization of cocaine and opiate polydrug abuse, a growing subset of the drug abuse population. Considerable advances have also been made in understanding how chronic and persistent drug use induces biochemical and molecular biologic adaptations in brain regions related to drug reinforcement.

MeSH Terms
Animals Cocaine/pharmacology Disease Models, Animal Dopamine Uptake Inhibitors/pharmacology Humans Rats Receptors, Dopamine/physiology Reinforcement, Psychology Substance-Related Disorders/physiopathology
Chemicals
Dopamine Uptake Inhibitors Receptors, Dopamine Cocaine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hemby S E
Neuroscience Division, 1026 Yerkes Regional Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
References (46)
46 references, click to expand
  1. Molecular mechanisms of drug reinforcement and addiction.
    Annu Rev Neurosci. 1995;18:463-95 PMID: 7605071
  2. Effects of single and repeated morphine administration on the prodynorphin, proenkephalin and dopamine D2 receptor gene expression in the mouse brain.
    Neuropeptides. 1997 Feb;31(1):24-8 PMID: 9574833
  3. A primate model of polydrug abuse: cocaine and heroin combinations.
    J Pharmacol Exp Ther. 1995 Sep;274(3):1325-37 PMID: 7562505
  4. Self-administration of cocaine-heroin combinations by rhesus monkeys: antagonism by naltrexone.
    J Pharmacol Exp Ther. 1998 Jul;286(1):61-9 PMID: 9655842
  5. Regulation of cocaine reward by CREB.
    Science. 1998 Dec 18;282(5397):2272-5 PMID: 9856954
  6. Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement.
    J Neurosci. 1994 Oct;14(10):6239-47 PMID: 7931576
  7. Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya.
    J Neurosci. 1993 Jan;13(1):276-84 PMID: 8380850
  8. Synergistic elevations in nucleus accumbens extracellular dopamine concentrations during self-administration of cocaine/heroin combinations (Speedball) in rats.
    J Pharmacol Exp Ther. 1999 Jan;288(1):274-80 PMID: 9862781
  9. The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.
    J Pharmacol Exp Ther. 1996 Jun;277(3):1247-58 PMID: 8667185
  10. The synergistic effects of combining cocaine and heroin ("speedball") using a progressive-ratio schedule of drug reinforcement.
    Pharmacol Biochem Behav. 1998 Nov;61(3):297-302 PMID: 9768564
  11. Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
    Brain Res Mol Brain Res. 1997 Apr;45(1):149-53 PMID: 9105683
  12. Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration.
    Synapse. 1995 Oct;21(2):140-8 PMID: 8584975
  13. A psychomotor stimulant theory of addiction.
    Psychol Rev. 1987 Oct;94(4):469-92 PMID: 3317472
  14. Relationship between subjective effects of cocaine and dopamine transporter occupancy.
    Nature. 1997 Apr 24;386(6627):827-30 PMID: 9126740
  15. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum.
    Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7005-9 PMID: 8346209
  16. Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
    J Pharmacol Exp Ther. 1996 Jan;276(1):306-15 PMID: 8558448
  17. Amygdala dopamine levels are markedly elevated after self- but not passive-administration of cocaine.
    Brain Res. 1994 Dec 30;668(1-2):39-45 PMID: 7704616
  18. Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization.
    Brain Res. 1997 Feb 21;749(1):120-6 PMID: 9070635
  19. The effects of buprenorphine on self-administration of cocaine and heroin "speedball" combinations and heroin alone by rhesus monkeys.
    J Pharmacol Exp Ther. 1998 May;285(2):444-56 PMID: 9580582
  20. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum.
    Neuron. 1995 Apr;14(4):813-23 PMID: 7718243
  21. Functional consequences of acute cocaine treatment depend on route of administration.
    Psychopharmacology (Berl). 1993;112(2-3):343-51 PMID: 7871040
  22. Under siege: The brain on opiates.
    Neuron. 1996 May;16(5):897-900 PMID: 8630245
  23. Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment.
    Neuropsychopharmacology. 1998 Mar;18(3):222-32 PMID: 9471119
  24. Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system.
    Synapse. 1992 Nov;12(3):242-53 PMID: 1362292
  25. Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptors: an in vivo fast-cyclic voltammetry study.
    J Pharmacol Exp Ther. 1998 Jan;284(1):151-61 PMID: 9435173
  26. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos.
    Mol Cell Biol. 1998 Feb;18(2):967-77 PMID: 9447994
  27. Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area.
    Brain Res. 1992 May 8;579(2):181-6 PMID: 1628210
  28. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
    J Pharmacol Exp Ther. 1995 Sep;274(3):1182-91 PMID: 7562486
  29. Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys.
    J Neurosci. 1996 Feb 1;16(3):1230-8 PMID: 8558251
  30. Drug addiction: a model for the molecular basis of neural plasticity.
    Neuron. 1993 Dec;11(6):995-1006 PMID: 8274284
  31. Limbic activation during cue-induced cocaine craving.
    Am J Psychiatry. 1999 Jan;156(1):11-8 PMID: 9892292
  32. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function.
    Brain Res. 1991 May 10;548(1-2):100-10 PMID: 1651140
  33. Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.
    Arch Gen Psychiatry. 1997 Aug;54(8):713-20 PMID: 9283506
  34. Mu and delta opioid receptor gene expression after chronic treatment with opioid agonist.
    Neuroreport. 1996 Jun 17;7(9):1505-8 PMID: 8856708
  35. The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis.
    J Pharmacol Exp Ther. 1995 May;273(2):591-8 PMID: 7752060
  36. Persistence of neurochemical changes in dopamine systems after repeated cocaine administration.
    J Pharmacol Exp Ther. 1990 Apr;253(1):38-44 PMID: 2329520
  37. Sensitization to morphine induced by viral-mediated gene transfer.
    Science. 1997 Aug 8;277(5327):812-4 PMID: 9242609
  38. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat.
    Psychopharmacology (Berl). 1997 Sep;133(1):7-16 PMID: 9335075
  39. Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys.
    Synapse. 1998 Sep;30(1):88-96 PMID: 9704885
  40. Intravenous self-administration of heroin, cocaine, and the combination in Balb/c mice.
    Eur J Pharmacol. 1997 May 20;326(2-3):119-25 PMID: 9196263
  41. The effect of single and repeated morphine administration on the prodynorphin system activity in the nucleus accumbens and striatum of the rat.
    Neuroscience. 1996 Feb;70(3):749-54 PMID: 9045086
  42. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors.
    Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8537-41 PMID: 8078918
  43. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
    Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8 PMID: 2899326
  44. Chronic opiate agonists down-regulate prodynorphin gene expression in rat brain.
    Brain Res. 1991 Nov 1;563(1-2):132-6 PMID: 1786525
  45. Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain.
    J Neurochem. 1990 Sep;55(3):1079-82 PMID: 2117048
  46. Delayed occurrence of enhanced striatal preprodynorphin gene expression in behaviorally sensitized rats: differential long-term effects of intermittent and chronic morphine administration.
    Neuroscience. 1997 Jan;76(1):167-76 PMID: 8971769
Article Info
Journal
Current psychiatry reports
Abbr.
Curr Psychiatry Rep
ISSN
1523-3812
DOI
10.1007/s11920-999-0026-9
Published
1999-12-00
Pages
159-65
Language
English
Region
United States
NLM ID
100888960
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1007/s11920-999-0026-9 View journal details
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