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PMID: 17008174 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

The Lancet. Infectious diseases ·Vol. 6 ·No. 10 ·2006-10-00 ·Pages 653-63

Burgner D, Jamieson SE, Blackwell JM

Abstract

Genetic epidemiology, including twin studies, provides robust evidence that genetic variation in human populations contributes to susceptibility to infectious disease. One of the major limitations of studies that attempt to identify the genes and mechanisms that underlie this susceptibility has been lack of power caused by small sample size. With the development of novel technologies, burgeoning information on the human genome, the HapMap project, and human genetic diversity, we are at the beginning of a new era in the study of the genetics of complex diseases. This review looks afresh at the epidemiological evidence that supports a role for genetics in susceptibility to infectious disease, examines the somewhat limited achievements to date, and discusses current advances in methodology and technology that will potentially lead to translational data in the future.

MeSH Terms
Communicable Diseases/epidemiology,genetics Genetic Linkage Genetic Predisposition to Disease Genetic Techniques Genetic Variation Genome, Human Humans Immunity/genetics Twin Studies as Topic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Burgner David
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, WA, Australia.
Jamieson Sarra E
Blackwell Jenefer M
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Article Info
Journal
The Lancet. Infectious diseases
Abbr.
Lancet Infect Dis
ISSN
1473-3099
DOI
10.1016/S1473-3099(06)70601-6
Published
2006-10-00
Pages
653-63
Language
English
Region
United States
NLM ID
101130150
PMCID
PMC2330096
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 065642 · United Kingdom
Wellcome Trust · 074196 · United Kingdom
External Links
PubMed source DOI: 10.1016/S1473-3099(06)70601-6 PMC Full Text View journal details
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