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PMID: 9038290 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.

Infection and immunity ·Vol. 65 ·No. 3 ·1997-03-00 ·Pages 872-6

Jepson A, Banya W, Sisay-Joof F, Hassan-King M, Nunes C, Bennett S, Whittle H

Abstract

Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gambian twins we report that regulation of the immune response to a variety of antigens from Plasmodium falciparum and Mycobacterium tuberculosis is controlled by factors which are encoded by genes that lie both within and outside the major histocompatibility complex (MHC). We define the relative contribution of these genes, which varies for different antigens. The cumulative genetic contribution of non-MHC genes to the total phenotypic variance exceeds that of the MHC-encoded genes.

MeSH Terms
Antibody Formation/genetics Antigens, Bacterial/immunology Antigens, Protozoan/immunology Genes, MHC Class II Humans Lymphocyte Activation/genetics Major Histocompatibility Complex/physiology Twins
Chemicals
Antigens, Bacterial Antigens, Protozoan
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Jepson A
MRC Laboratories, Fajara, The Gambia.
Banya W
Sisay-Joof F
Hassan-King M
Nunes C
Bennett S
Whittle H
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.65.3.872-876.1997
Published
1997-03-00
Pages
872-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC175062
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.65.3.872-876.1997 PMC Full Text View journal details
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