Home LiteratureArticle Details
PMID: 15742161 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunological status in the aetiology of recurrent otitis media with effusion: serum immunoglobulin levels, functional mannose-binding lectin and Fc receptor polymorphisms for IgG.

Journal of clinical immunology ·Vol. 25 ·No. 1 ·2005-01-00 ·Pages 78-86

Straetemans M, Wiertsema SP, Sanders EA, Rijkers GT, Graamans K, van der Baan B, Zielhuis GA

Abstract

The objective was to study the role of serum immunoglobulin levels, mannose-binding lectin (MBL), and Fc gamma receptor (FcgammaR) polymorphisms on the development of recurrent otitis media with effusion (OME). Children aged between two and seven years with persisting OME received bilateral tympanostomy tubes and immunological parameters were investigated in relation with OME recurrence within six months after tube extrusion. No statistically significant differences in serum immunoglobulin levels were present between children with and without OME recurrence. In children with bilateral recurrence (n = 56), median levels of MBL were 1.39 mg/L compared to 2.48 mg/L in children with OME recurrence (n = 17) (p = 0.29). In addition, 34% of the children with bilateral recurrence were homozygous for the genotype FcgammaRIIa-R/R131, whereas less than 20% of the children with unilateral recurrence or those without recurrence were homozygous for this Fcgamma receptor (p = 0.26). Serum mannose-binding lectin and FcgammaRIIa-R/R131 polymorphism may play a role in the aetio-pathogenesis of recurrent OME.

MeSH Terms
Child Child, Preschool Homozygote Humans Immunoglobulin G/blood Immunoglobulins/blood,immunology Mannose-Binding Lectin/blood Otitis Media with Effusion/genetics,immunology Polymorphism, Genetic Receptors, IgG/blood,genetics Recurrence
Chemicals
Immunoglobulin G Immunoglobulins Mannose-Binding Lectin Receptors, IgG
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Straetemans Masja
Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
Wiertsema Selma P
Sanders Elisabeth A M
Rijkers Ger T
Graamans Kees
van der Baan Bert
Zielhuis Gerhard A
References (37)
37 references, click to expand
  1. Serum IgA and IgG functional antibodies and their subclasses to Streptococcus pneumoniae capsular antigen found in two aged-matched cohorts of children with and without otitis media with effusion.
    Clin Otolaryngol Allied Sci. 2003 Aug;28(4):335-40 PMID: 12871248
  2. Clinical experience with impedance audiometry.
    Arch Otolaryngol. 1970 Oct;92(4):311-24 PMID: 5455571
  3. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood.
    JAMA. 2001 Mar 14;285(10):1316-21 PMID: 11255386
  4. Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency.
    Lancet. 1995 Oct 7;346(8980):941-3 PMID: 7564730
  5. Association of human Fc gamma RIIa (CD32) polymorphism with susceptibility to and severity of meningococcal disease.
    Clin Infect Dis. 1998 Oct;27(4):746-50 PMID: 9798027
  6. Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion.
    N Engl J Med. 1987 Dec 3;317(23):1444-51 PMID: 3683478
  7. Sequelae of recurrent acute otitis media. Ten-year follow-up of a prospectively studied cohort of children.
    Acta Paediatr. 1997 Nov;86(11):1208-13 PMID: 9401515
  8. The prevalence of otitis media with effusion: a critical review of the literature.
    Clin Otolaryngol Allied Sci. 1990 Jun;15(3):283-8 PMID: 2203566
  9. Pneumococcal antibodies and complement during and after periods of recurrent otitis.
    Int J Pediatr Otorhinolaryngol. 1984 Mar;7(1):39-49 PMID: 6724809
  10. Immunochemical quantitation of antigens by single radial immunodiffusion.
    Immunochemistry. 1965 Sep;2(3):235-54 PMID: 4956917
  11. IgG-Fc receptors and the clinical relevance of their polymorphisms.
    Wien Klin Wochenschr. 2001 Oct 30;113(20-21):825-31 PMID: 11732118
  12. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children.
    Clin Exp Immunol. 1984 May;56(2):233-8 PMID: 6733969
  13. Evidence for non-random distribution of Fcgamma receptor genotype combinations.
    Immunogenetics. 2003 Jul;55(4):240-6 PMID: 12830330
  14. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients.
    Rheumatology (Oxford). 2001 Sep;40(9):1009-12 PMID: 11561111
  15. Hearing deficits at school age; the predictive value of otitis media in infants.
    Int J Pediatr Otorhinolaryngol. 1998 Aug 1;44(3):227-34 PMID: 9780068
  16. The significance of IgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency.
    Clin Exp Immunol. 1999 Jun;116(3):505-8 PMID: 10361242
  17. A hemolytic assay for the estimation of functional mannose-binding lectin levels in human serum.
    J Immunol Methods. 2002 Oct 15;268(2):149-57 PMID: 12215383
  18. The occurrence of otitis media with effusion in Dutch pre-school children.
    Clin Otolaryngol Allied Sci. 1990 Apr;15(2):147-53 PMID: 2350892
  19. IgG Fc-receptor polymorphisms in Guillain-Barré syndrome.
    Neurology. 2000 Sep 12;55(5):705-7 PMID: 10980740
  20. Immunoglobulin G, total and subclass, in children with or without recurrent otitis media.
    J Pediatr. 1992 Aug;121(2):249-51 PMID: 1640291
  21. Fc gamma receptor IIa (CD32) heterogeneity in patients with recurrent bacterial respiratory tract infections.
    J Infect Dis. 1994 Oct;170(4):854-61 PMID: 7930727
  22. A comprehensive model for the aetiology of otitis media with effusion.
    Med Hypotheses. 2001 Dec;57(6):784-91 PMID: 11918448
  23. Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease.
    Am J Med. 2002 Jan;112(1):19-25 PMID: 11812402
  24. Long-term effects of otitis media with effusion: otomicroscopic findings.
    Am J Otol. 1995 May;16(3):365-72 PMID: 8588632
  25. The effect of otitis media with effusion at preschool age on some aspects of auditory perception at school age.
    Ear Hear. 1994 Jun;15(3):224-31 PMID: 8076720
  26. Mannan-binding protein--levels in plasma and upper-airways secretions and frequency of genotypes in children with recurrence of otitis media.
    Clin Exp Immunol. 1993 Oct;94(1):99-104 PMID: 8403525
  27. No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.
    J Neuroimmunol. 2003 Jul;140(1-2):210-5 PMID: 12864991
  28. Variant genotypes of the low-affinity Fcgamma receptors in two control populations and a review of low-affinity Fcgamma receptor polymorphisms in control and disease populations.
    Blood. 1999 Dec 15;94(12):4220-32 PMID: 10590067
  29. Fc-gamma receptors: mediators, targets and markers of disease.
    Baillieres Clin Haematol. 1991 Dec;4(4):889-902 PMID: 1790356
  30. Immunological deficiency in "otitis-prone" children.
    Ann N Y Acad Sci. 1997 Dec 29;830:70-81 PMID: 9616668
  31. Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.
    J Infect Dis. 2001 Dec 15;184(12):1548-55 PMID: 11740730
  32. MBL genotype and risk of invasive pneumococcal disease: a case-control study.
    Lancet. 2002 May 4;359(9317):1569-73 PMID: 12047967
  33. Chronic otitis media with effusion.
    Pediatr Rev. 1999 Mar;20(3):85-93; quiz 94 PMID: 10073070
  34. Prevalence rates of otitis media with effusion from 0 to 2 years of age: healthy-born versus high-risk-born infants.
    Int J Pediatr Otorhinolaryngol. 1999 Mar 15;47(3):243-51 PMID: 10321779
  35. IgG receptor polymorphisms: risk factors for disease.
    Immunogenetics. 1998 Aug;48(3):222-32 PMID: 9683667
  36. Lack of association between mannose-binding lectin, acute otitis media and early Epstein-Barr virus infection among children in Greenland.
    Scand J Infect Dis. 1999;31(4):363-6 PMID: 10528874
  37. Molecular basis of opsonic defect in immunodeficient children.
    Lancet. 1991 Jun 29;337(8757):1569-70 PMID: 1675710
Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/s10875-005-0361-8
Published
2005-01-00
Pages
78-86
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/s10875-005-0361-8 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2