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PMID: 16709670 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structural and functional recovery from early monocular deprivation in adult rats.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 103 ·No. 22 ·2006-05-30 ·Pages 8517-22

Pizzorusso T, Medini P, Landi S, Baldini S, Berardi N, Maffei L

Abstract

Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular deprivation. We found that chondroitinase ABC treatment coupled with reverse lid-suturing causes a complete recovery of ocular dominance, visual acuity, and dendritic spine density in adult rats. Thus, manipulations of the extracellular matrix can be used to promote functional recovery in the adult cortex.

MeSH Terms
Aging/physiology Animals Behavior, Animal Chondroitin ABC Lyase/pharmacology Electrophysiology Rats Spine/drug effects,pathology Time Factors Vision Disorders/drug therapy,physiopathology Vision, Monocular/drug effects,physiology Visual Cortex/drug effects,physiopathology
Chemicals
Chondroitin ABC Lyase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Pizzorusso Tommaso
Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Via Moruzzi 1, 56100 Pisa, Italy. tommaso@in.cnr.it
Medini Paolo
Landi Silvia
Baldini Sara
Berardi Nicoletta
Maffei Lamberto
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0602657103
Email
tommaso@in.cnr.it
Published
2006-05-30
Epub
2006-00-18
Pages
8517-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1482523
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0602657103 PMC Full Text View journal details
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