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PMID: 1924342 Published · ppublish English Journal Article

Nerve growth factor prevents the amblyopic effects of monocular deprivation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 19 ·1991-10-01 ·Pages 8811-5

Domenici L, Berardi N, Carmignoto G, Vantini G, Maffei L

Abstract

Monocular deprivation early in life causes dramatic changes in the functional organization of mammalian visual cortex and severe reduction in visual acuity and contrast sensitivity of the deprived eye. We tested whether or not these changes could be from competition between the afferents from the two eyes for a target-derived neurotrophic factor. Rats monocularly deprived during early postnatal development were treated with repetitive intraventricular injections or topical administration of nerve growth factor. The effects of monocular deprivation were then assessed electrophysiologically. In untreated animals visual acuity and contrast sensitivity of the deprived eye were strongly reduced, whereas in nerve growth factor-treated animals these parameters were normal.

MeSH Terms
Amblyopia/prevention & control Animals Choline O-Acetyltransferase/metabolism Injections, Intraventricular Nerve Growth Factors/pharmacology Neuronal Plasticity Rats Sensory Deprivation/physiology Visual Acuity/drug effects Visual Cortex/drug effects Visual Pathways/growth & development
Chemicals
Nerve Growth Factors Choline O-Acetyltransferase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Domenici L
Istituto di Neurofisiologia, Consiglio Nazionale delle Ricerche, Pisa, Italy.
Berardi N
Carmignoto G
Vantini G
Maffei L
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.19.8811
Published
1991-10-01
Pages
8811-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52600
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.88.19.8811 PMC Full Text View journal details
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