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PMID: 16582424 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Telomeric silencing of an open reading frame in Saccharomyces cerevisiae.

Genetics ·Vol. 173 ·No. 2 ·2006-06-00 ·Pages 1169-73

Barton AB, Kaback DB

Abstract

The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.

MeSH Terms
Base Sequence Chromosomes, Fungal/genetics DNA, Fungal/genetics Gene Silencing Genes, Fungal Mutation Open Reading Frames Saccharomyces cerevisiae/genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics Telomere/genetics
Chemicals
DNA, Fungal SIR3 protein, S cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Barton Arnold B
Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA.
Kaback David B
References (22)
22 references, click to expand
  1. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.
    Nature. 1999 Nov 25;402(6760):418-21 PMID: 10586882
  2. Epigenetic silencing mechanisms in budding yeast and fruit fly: different paths, same destinations.
    Mol Cell. 2005 May 13;18(4):395-8 PMID: 15893722
  3. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast.
    J Biol Chem. 2003 Aug 1;278(31):28470-8 PMID: 12746440
  4. A function for subtelomeric DNA in Saccharomyces cerevisiae.
    Genetics. 2003 Oct;165(2):929-34 PMID: 14573499
  5. Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast.
    Cell. 2004 Feb 6;116(3):405-15 PMID: 15016375
  6. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  7. One-step gene disruption in yeast.
    Methods Enzymol. 1983;101:202-11 PMID: 6310324
  8. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.
    Methods Enzymol. 1987;155:335-50 PMID: 3431465
  9. Enhanced meiotic recombination on the smallest chromosome of Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 1989 May;86(10):3694-8 PMID: 2657726
  10. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
    Cell. 1990 Nov 16;63(4):751-62 PMID: 2225075
  11. The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants.
    Mol Cell Biol. 1991 Apr;11(4):2253-62 PMID: 2005909
  12. Physical localization of yeast CYS3, a gene whose product resembles the rat gamma-cystathionase and Escherichia coli cystathionine gamma-synthase enzymes.
    Yeast. 1993 Apr;9(4):363-9 PMID: 8511966
  13. Physical maps of the six smallest chromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairs.
    Genetics. 1993 May;134(1):81-150 PMID: 8514151
  14. Specific repression of the yeast silent mating locus HMR by an adjacent telomere.
    Mol Cell Biol. 1994 Jan;14(1):446-55 PMID: 8264612
  15. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region.
    J Bacteriol. 1994 Apr;176(7):1872-80 PMID: 8144453
  16. The chromosome ends of Saccharomyces cerevisiae.
    Yeast. 1995 Dec;11(16):1553-73 PMID: 8720065
  17. Biochemical properties and excretion behavior of repressible acid phosphatases with altered subunit composition.
    Microbiol Res. 1996 Aug;151(3):291-300 PMID: 8817921
  18. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: characterization of the 54 kb right terminal CDC15-FLO1-PHO11 region.
    Yeast. 1997 Oct;13(13):1251-63 PMID: 9364749
  19. Saccharomyces cerevisiae telomeres. A review.
    Biochemistry (Mosc). 1997 Nov;62(11):1232-41 PMID: 9467847
  20. Drug-induced phenotypes provide a tool for the functional analysis of yeast genes.
    Yeast. 1998 Jul;14(10):935-42 PMID: 9717239
  21. Conservation of ARS elements and chromosomal DNA replication origins on chromosomes III of Saccharomyces cerevisiae and S. carlsbergensis.
    Genetics. 1999 Jul;152(3):933-41 PMID: 10388813
  22. Telomeric silencing of a natural subtelomeric gene.
    Mol Gen Genet. 2000 Mar;263(2):287-91 PMID: 10778747
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.106.058420
Published
2006-06-00
Epub
2006-00-02
Pages
1169-73
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1526490
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053924 · United States
NIGMS NIH HHS · GM053924 · United States
External Links
PubMed source DOI: 10.1534/genetics.106.058420 PMC Full Text View journal details
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