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PMID: 16482094 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Cell-signalling dynamics in time and space.

Nature reviews. Molecular cell biology ·Vol. 7 ·No. 3 ·2006-03-00 ·Pages 165-76

Kholodenko BN

Abstract

The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to spatial gradients of signalling activities, which guide pivotal intracellular processes and tightly regulate signal propagation across a cell. Computational models provide insights into the complex relationships between the stimuli and the cellular responses, and reveal the mechanisms that are responsible for signal amplification, noise reduction and generation of discontinuous bistable dynamics or oscillations.

MeSH Terms
Animals Cell Physiological Phenomena Humans Kinetics Models, Biological Receptor Protein-Tyrosine Kinases/metabolism Receptors, G-Protein-Coupled/physiology Signal Transduction/physiology
Chemicals
Receptors, G-Protein-Coupled Receptor Protein-Tyrosine Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kholodenko Boris N
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA. Boris.Kholodenko@jefferson.edu
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/nrm1838
Email
boris.kholodenko@jefferson.edu
Published
2006-03-00
Pages
165-76
Language
English
Region
England
NLM ID
100962782
PMCID
PMC1679905
Subset
IM
Grants
NIGMS NIH HHS · R01 GM059570 · United States
External Links
PubMed source DOI: 10.1038/nrm1838 PMC Full Text View journal details
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