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PMID: 16314451 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

MicroRNA function: multiple mechanisms for a tiny RNA?

RNA (New York, N.Y.) ·Vol. 11 ·No. 12 ·2005-12-00 ·Pages 1753-61

Pillai RS

Abstract

MicroRNAs are sequence-specific regulators of post-transcriptional gene expression in many eukaryotes. They are believed to control the expression of thousands of target mRNAs, with each mRNA believed to be targeted by multiple microRNAs. Recent studies have uncovered various mechanisms by which microRNAs down-regulate their target mRNAs and have linked a well-known subcellular structure, the cytoplasmic processing bodies (PBs) to the microRNA pathway. The finding that microRNAs are misexpressed in cancers has reinforced the idea that their regulatory roles are very important.

MeSH Terms
Animals Gene Expression Regulation Humans MicroRNAs/biosynthesis,genetics,metabolism Models, Biological RNA Processing, Post-Transcriptional RNA, Messenger/genetics,metabolism
Chemicals
MicroRNAs RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pillai Ramesh S
Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland. ramesh.pillai@fmi.ch
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Article Info
Journal
RNA (New York, N.Y.)
Abbr.
RNA
ISSN
1355-8382
DOI
10.1261/rna.2248605
Email
ramesh.pillai@fmi.ch
Published
2005-12-00
Pages
1753-61
Language
English
Region
United States
NLM ID
9509184
PMCID
PMC1370863
Subset
IM
External Links
PubMed source DOI: 10.1261/rna.2248605 PMC Full Text View journal details
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