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PMID: 16155571 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells.

Nature immunology ·Vol. 6 ·No. 10 ·2005-10-00 ·Pages 1029-37

Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH

Abstract

Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow-resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell-mediated recall responses in the bone marrow.

MeSH Terms
Animals Blood Vessels/metabolism Bone Marrow/blood supply,immunology Cell Movement Dendritic Cells/immunology Endothelium, Vascular/metabolism Immunologic Memory Lymphocyte Activation Mice Mice, Congenic Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Selectins/metabolism T-Lymphocytes/immunology Vascular Cell Adhesion Molecule-1/metabolism
Chemicals
Selectins Vascular Cell Adhesion Molecule-1
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Cavanagh Lois L
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Bonasio Roberto
Mazo Irina B
Halin Cornelia
Cheng Guiying
van der Velden Adrianus W M
Cariappa Annaiah
Chase Catherine
Russell Paul
Starnbach Michael N
Koni Pandelakis A
Pillai Shiv
Weninger Wolfgang
von Andrian Ulrich H
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2908
DOI
10.1038/ni1249
Published
2005-10-00
Epub
2005-00-11
Pages
1029-37
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC1780273
Subset
IM
Grants
NIAID NIH HHS · AI061663 · United States
NHLBI NIH HHS · HL56949 · United States
NHLBI NIH HHS · HL54936 · United States
NHLBI NIH HHS · HL62524 · United States
NHLBI NIH HHS · R01 HL054936 · United States
NHLBI NIH HHS · P01 HL056949 · United States
NIAID NIH HHS · R01 AI061663 · United States
External Links
PubMed source DOI: 10.1038/ni1249 PMC Full Text View journal details
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