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PMID: 15538380 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The E2F family: specific functions and overlapping interests.

The EMBO journal ·Vol. 23 ·No. 24 ·2004-12-08 ·Pages 4709-16

Attwooll C, Lazzerini Denchi E, Helin K

Abstract

The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.

MeSH Terms
Animals Cell Cycle/physiology Cell Cycle Proteins/classification,genetics,metabolism Cell Proliferation DNA-Binding Proteins/classification,genetics,metabolism E2F Transcription Factors Gene Expression Regulation Phenotype Protein Binding Transcription Factors/classification,genetics,metabolism
Chemicals
Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Attwooll Claire
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Lazzerini Denchi Eros
Helin Kristian
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1038/sj.emboj.7600481
Published
2004-12-08
Epub
2004-00-11
Pages
4709-16
Language
English
Region
England
NLM ID
8208664
PMCID
PMC535093
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.emboj.7600481 PMC Full Text View journal details
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