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PMID: 1541542 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor.

Infection and immunity ·Vol. 60 ·No. 3 ·1992-03-00 ·Pages 1249-53

Chatterjee D, Roberts AD, Lowell K, Brennan PJ, Orme IM

Abstract

The results of this study show that lipoarabinomannans (LAM) isolated from a virulent strain and from an avirulent strain of Mycobacterium tuberculosis, which have recently been shown to differ markedly in terms of the structures of their nonreducing termini, also differ markedly in the capacity to induce the secretion of tumor necrosis factor from murine macrophages. It was found that LAM from the avirulent H37Ra strain was 100-fold more potent at inducing tumor necrosis factor secretion than LAM from the virulent Erdman strain, thus leading us to hypothesize that the structure of LAM from a given mycobacterial isolate may directly influence its ability to elicit, or avoid, cytokine-mediated mechanisms of host resistance.

MeSH Terms
Animals Female Lipopolysaccharides/toxicity Mice Mice, Inbred C3H Mice, Inbred C57BL Mycobacterium tuberculosis/pathogenicity Structure-Activity Relationship Tumor Necrosis Factor-alpha/metabolism Virulence
Chemicals
Lipopolysaccharides Tumor Necrosis Factor-alpha lipoarabinomannan
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Chatterjee D
Department of Microbiology, Colorado State University, Fort Collins 80523.
Roberts A D
Lowell K
Brennan P J
Orme I M
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.3.1249-1253.1992
Published
1992-03-00
Pages
1249-53
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257623
Subset
IM
Grants
NIAID NIH HHS · AI 27288 · United States
External Links
PubMed source DOI: 10.1128/iai.60.3.1249-1253.1992 PMC Full Text View journal details
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