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PMID: 3351436 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

The Journal of experimental medicine ·Vol. 167 ·No. 3 ·1988-03-01 ·Pages 1211-27

Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, Kuo GC, Beutler B, Cotran RS, Cerami A

Abstract

Cachexia is a potentially lethal syndrome of unknown etiology characterized by anorexia, weight loss, and protein wasting that frequently complicates the treatment of chronic inflammation and cancer. Cachectin/TNF was isolated during the search for a humoral mediator of cachexia and found to stimulate the breakdown of energy stores from adipocytes and myocytes in vitro, but the chronic effects of the monokine in vivo are not known. Sublethal doses of recombinant human cachectin administered twice daily for 7-10 d caused cachexia in rats, as evidenced by reduced food intake, weight loss, and depletion of whole-body lipid and protein stores. Significant anemia is also observed and found to be the result of decreased red blood cell mass, not expanded plasma volume. Leukocytosis and histopathological evidence of tissue injury and inflammation are observed in several organs, including omentum, liver, spleen, and heart. These data suggests that the exposure of the normal host to cachectin is capable of inducing a pathophysiological syndrome of cachexia, anemia, and inflammation similar to that observed during inflammatory states or malignancy.

MeSH Terms
Anemia/chemically induced,pathology Animals Body Composition/drug effects Body Weight/drug effects Cachexia/chemically induced,pathology Feeding Behavior/drug effects Female Inflammation/chemically induced Leukocytosis/chemically induced Rats Rats, Inbred Strains Recombinant Proteins/toxicity Tumor Necrosis Factor-alpha/toxicity
Chemicals
Recombinant Proteins Tumor Necrosis Factor-alpha
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Tracey K J
Laboratory of Surgical Metabolism, New York Hospital-Cornell University Medical Center, New York, New York 10021.
Wei H
Manogue K R
Fong Y
Hesse D G
Nguyen H T
Kuo G C
Beutler B
Cotran R S
Cerami A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.167.3.1211
Published
1988-03-01
Pages
1211-27
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188883
Subset
IM
Grants
NIGMS NIH HHS · GM-23000 · United States
NIGMS NIH HHS · GM-34695 · United States
NIGMS NIH HHS · K04GM-00505 · United States
External Links
PubMed source DOI: 10.1084/jem.167.3.1211 PMC Full Text View journal details
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