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PMID: 15381634 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.

British journal of pharmacology ·Vol. 143 ·No. 5 ·2004-11-00 ·Pages 520-3

Tucci SA, Rogers EK, Korbonits M, Kirkham TC

Abstract

The paraventricular nucleus (PVN) of the hypothalamus plays a key role in the control of appetite and energy balance. Both ghrelin and cannabinoid receptor agonists increase food intake when administered into this nucleus: this study investigated possible interactions between the two systems in relation to eating. The orexigenic effect of ghrelin (100 pmol) when infused in to the PVN was reversed by a small, systemic dose of the CB(1) cannabinoid receptor antagonist SR141716 (1 mg kg(-1)). This is the first demonstration of a functional relationship between brain ghrelin and endocannabinoid systems, and, although it needs to be further investigated, the effect of ghrelin on food intake when injected into the PVN seems to be mediated by stimulation of cannabinoid release.

MeSH Terms
Animals Appetite Stimulants/administration & dosage,antagonists & inhibitors Dronabinol/antagonists & inhibitors,pharmacology Eating/drug effects Ghrelin Male Microinjections Paraventricular Hypothalamic Nucleus/physiology Peptide Hormones/administration & dosage,antagonists & inhibitors,pharmacology Piperidines/pharmacology Pyrazoles/pharmacology Rats Receptor, Cannabinoid, CB1/drug effects Rimonabant
Chemicals
Appetite Stimulants Ghrelin Peptide Hormones Piperidines Pyrazoles Receptor, Cannabinoid, CB1 Dronabinol Rimonabant
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tucci Sonia A
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA.
Rogers Elizabeth K
Korbonits Marta
Kirkham Tim C
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1038/sj.bjp.0705968
Published
2004-11-00
Epub
2004-00-20
Pages
520-3
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1575431
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjp.0705968 PMC Full Text View journal details
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