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PMID: 8688086 Published · ppublish English Journal Article

A receptor in pituitary and hypothalamus that functions in growth hormone release.

Science (New York, N.Y.) ·Vol. 273 ·No. 5277 ·1996-08-16 ·Pages 974-7

Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH

Abstract

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Line Codon DNA, Complementary/genetics GTP-Binding Proteins/metabolism Growth Hormone/metabolism Hormones/metabolism Humans Hypothalamus, Middle/chemistry Indoles/metabolism,pharmacology Macaca mulatta Molecular Sequence Data Oligopeptides/metabolism Pituitary Gland/chemistry RNA, Complementary/genetics Rats Receptors, Cell Surface/analysis,chemistry,genetics,metabolism Receptors, G-Protein-Coupled Receptors, Ghrelin Spiro Compounds/metabolism,pharmacology Swine

Chemicals

Codon DNA, Complementary Hormones Indoles Oligopeptides RNA, Complementary Receptors, Cell Surface Receptors, G-Protein-Coupled Receptors, Ghrelin Spiro Compounds growth hormone releasing hexapeptide Growth Hormone GTP-Binding Proteins ibutamoren mesylate

Authors & Affiliations

32 authors, click to expand affiliations / ORCID

Howard A D

Merck Research Laboratories, Rahway, NJ 07065, USA.

Feighner S D

Cully D F

Arena J P

Liberator P A

Rosenblum C I

Hamelin M

Hreniuk D L

Palyha O C

Anderson J

Paress P S

Diaz C

Chou M

Liu K K

McKee K K

Pong S S

Chaung L Y

Elbrecht A

Dashkevicz M

Heavens R

Rigby M

Sirinathsinghji D J

Dean D C

Melillo D G

Patchett A A

Nargund R

Griffin P R

DeMartino J A

Gupta S K

Schaeffer J M

Smith R G

Van der Ploeg L H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.273.5277.974

Published

1996-08-16

Pages

974-7

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

U60178, U60179, U60180, U60181

Corrections

CommentIn

PMID: 8711477

External Links

PubMed source DOI: 10.1126/science.273.5277.974 View journal details

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A receptor in pituitary and hypothalamus that functions in growth hormone release.

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