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PMID: 12700881 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine.

Psychopharmacology ·Vol. 168 ·No. 3 ·2003-07-00 ·Pages 314-23

Verty AN, Singh ME, McGregor IS, Mallet PE

Abstract

Considerable interplay exists between the brain's opioid and cannabinoid systems. These systems are both involved in the control of appetite and research supports the notion that the opioid system modulates the role of the cannabinoid system on appetite. However, the ability of the cannabinoid system to modulate the opioid system's control over appetite has not been well studied. The present study examined the role of cannabinoid CB(1) receptors in the control of opioid-induced feeding, and sought to identify specific brain regions underlying this role. After being habituated to the test environment and injection procedure, sated rats were injected with the cannabinoid CB(1) receptor antagonist SR 141716 (0.03-3.0 mg/kg, IP). Thirty minutes later, morphine or its vehicle were administered systemically (2.5 mg/kg SC, experiments 1 and 2) or intracranially into the nucleus accumbens (nAcc, experiment 3) or paraventricular nucleus of the hypothalamus (PVN, experiment 4). Food intake and locomotor activity was then recorded for 120 min. A significant increase in food intake was observed following systemic and intracranial (10 nmol) application of morphine in all experiments. SR 141716 suppressed systemic and intra-PVN morphine induced feeding (experiments 2 and 4), but did not attenuate food intake induced by intra-nAcc application of morphine (experiment 3). Because SR 141716 had no effect on intra-nAcc morphine-stimulated feeding, it would appear that cannabinoid receptors do not modify opioid-mediated hedonic responses to food. Rather, we conclude that cannabinoid CB(1) receptor blockade may suppress opioid-induced feeding by stimulating the release of satiety-related peptides within the hypothalamus. Further, because SR 141716 did not block morphine induced locomotor activity, the observed effects on feeding do not appear to be due to a non-specific reduction in motivated behaviour.

MeSH Terms
Animals Appetite Depressants/administration & dosage,pharmacology Cannabinoid Receptor Agonists Cannabinoid Receptor Antagonists Feeding Behavior/drug effects Hyperphagia/psychology Injections Male Morphine/administration & dosage,pharmacology Motor Activity/drug effects Narcotics/administration & dosage,pharmacology Paraventricular Hypothalamic Nucleus Piperidines/administration & dosage,pharmacology Pyrazoles/administration & dosage,pharmacology Rats Rats, Wistar Receptor, Cannabinoid, CB1/antagonists & inhibitors Receptors, Opioid/agonists Rimonabant Stereotaxic Techniques
Chemicals
Appetite Depressants Cannabinoid Receptor Agonists Cannabinoid Receptor Antagonists Narcotics Piperidines Pyrazoles Receptor, Cannabinoid, CB1 Receptors, Opioid Morphine Rimonabant
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Verty Aaron N A
School of Psychology, University of New England, Armidale, 2351 NSW, Australia.
Singh Malini E
McGregor Iain S
Mallet Paul E
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/s00213-003-1451-9
Published
2003-07-00
Epub
2003-00-17
Pages
314-23
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/s00213-003-1451-9 View journal details
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