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PMID: 15359566 Published · ppublish English Journal Article Review

Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.

Pharmaceutical research ·Vol. 21 ·No. 8 ·2004-08-00 ·Pages 1313-30

Lee G, Bendayan R

Abstract

The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.

MeSH Terms
AIDS Dementia Complex/metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism Alzheimer Disease/metabolism Animals Blood-Brain Barrier/metabolism,ultrastructure Brain/metabolism Brain Neoplasms/metabolism Central Nervous System Diseases/drug therapy,etiology,metabolism Drug Resistance, Multiple Humans Parkinson Disease/metabolism
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lee Gloria
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada.
Bendayan Reina
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Article Info
Journal
Pharmaceutical research
Abbr.
Pharm Res
ISSN
0724-8741
DOI
10.1023/b:pham.0000036905.82914.8e
Published
2004-08-00
Pages
1313-30
Language
English
Region
United States
NLM ID
8406521
Subset
IM
External Links
PubMed source DOI: 10.1023/b:pham.0000036905.82914.8e View journal details
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