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PMID: 10696509 Published · ppublish English Journal Article Review

The choroid plexuses and the barriers between the blood and the cerebrospinal fluid.

Cellular and molecular neurobiology ·Vol. 20 ·No. 2 ·2000-04-00 ·Pages 183-96

Segal MB

Abstract

1. The fluid homeostasis of the brain depends both on the endothelial blood-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrier located at the choroid plexuses and the outer arachnoid membrane. 2. The brain has two fluid environments: the brain interstitial fluid, which surrounds the neurons and glia, and the CSF, which fills the ventricles and external surfaces of the central nervous system. 3. CSF acts as a fluid cushion for the brain and as a drainage route for the waste products of cerebral metabolism. 4. Recent findings suggest that CSF may also act as a "third circulation" conveying substances secreted into the CSF rapidly to many brain regions.

MeSH Terms
Animals Blood-Brain Barrier/physiology Capillary Permeability/physiology Cerebrospinal Fluid/physiology Choroid Plexus/blood supply,physiology Humans
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Segal M B
Division of Physiology, Guy's, King's and St. Thomas' School of Biomedical Sciences, King's College London, UK. malcolm.segal@kcl.ac.uk
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Article Info
Journal
Cellular and molecular neurobiology
Abbr.
Cell Mol Neurobiol
ISSN
0272-4340
DOI
10.1023/a:1007045605751
Email
malcolm.segal@kcl.ac.uk
Published
2000-04-00
Pages
183-96
Language
English
Region
United States
NLM ID
8200709
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1007045605751 View journal details
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