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PMID: 15289666 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology ·Vol. 12 ·No. 6 ·2004-00-00 ·Pages 599-616

Taylor SS, Scott MI, Holland AJ

Abstract

The centromere defines where on a chromosome the kinetochores assemble. Kinetochores, large protein structures, mediate chromosome segregation during mitosis and meiosis by performing three key functions. Firstly, kinetochores attach chromosomes to the microtubule spindle apparatus. Secondly, kinetochores co-ordinate microtubule dynamics to allow chromosomes to move along the spindle. Lastly, kinetochores generate the 'wait' signal which prevents anaphase onset until all the chromosomes are correctly aligned on the spindle. This signal forms part of the spindle checkpoint mechanism, a highly conserved cell cycle checkpoint which maintains the accuracy of the chromosome segregation process. This article provides a brief historical overview before focusing on some of the outstanding issues and more recent developments in the field.

MeSH Terms
Amino Acid Sequence Animals Calcium-Binding Proteins/metabolism Cell Cycle Proteins Chromosome Segregation Humans Kinetochores/metabolism Mad2 Proteins Molecular Sequence Data Neoplasms/genetics Protein Kinases/metabolism,physiology Protein Serine-Threonine Kinases Repressor Proteins Spindle Apparatus/metabolism,physiology
Chemicals
Calcium-Binding Proteins Cell Cycle Proteins MAD2L1 protein, human Mad2 Proteins Repressor Proteins Protein Kinases Bub1 spindle checkpoint protein Protein Serine-Threonine Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taylor Stephen S
School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom. stephen.taylor@man.ac.uk
Scott Maria I F
Holland Andrew J
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Article Info
Journal
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Abbr.
Chromosome Res
ISSN
0967-3849
DOI
10.1023/B:CHRO.0000036610.78380.51
Email
stephen.taylor@man.ac.uk
Published
2004-00-00
Pages
599-616
Language
English
Region
Netherlands
NLM ID
9313452
Subset
IM
External Links
PubMed source DOI: 10.1023/B:CHRO.0000036610.78380.51 View journal details
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