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PMID: 9864354 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis.

The Journal of cell biology ·Vol. 143 ·No. 7 ·1998-12-28 ·Pages 1775-87

Bernard P, Hardwick K, Javerzat JP

Abstract

The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle. We investigated the role of the fission yeast bub1 gene in spindle checkpoint function and in unperturbed mitoses. We find that bub1(+) is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. We show that Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. Such genomic instability is even more dramatic in Deltabub1 diploids, leading to massive chromosome missegregation events and loss of the diploid state, demonstrating that bub1(+ )function is essential to maintain correct ploidy through mitosis. As in larger eukaryotes, Bub1 is recruited to kinetochores during the early stages of mitosis. However, unlike its vertebrate counterpart, a pool of Bub1 remains centromere-associated at metaphase and even until telophase. We discuss the possibility of a role for the Bub1 kinase after the metaphase-anaphase transition.

MeSH Terms
Amino Acid Sequence Centromere/chemistry,physiology Chromosomes, Fungal/physiology Fungal Proteins/genetics,physiology Gene Deletion Mitosis/physiology Molecular Sequence Data Ploidies Protein Kinases/genetics,physiology Protein Serine-Threonine Kinases Schizosaccharomyces/genetics,physiology Sequence Alignment Sequence Homology, Amino Acid Spindle Apparatus/physiology
Chemicals
Fungal Proteins Protein Kinases Bub1 spindle checkpoint protein Protein Serine-Threonine Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bernard P
Institut de Biochimie et Génétique Cellulaires, Centre National de la Recherche Scientifique, Unité Propre de Recherche 9026, 33077 Bordeaux, Cedex, France.
Hardwick K
Javerzat J P
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
Published
1998-12-28
Pages
1775-87
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2175213
Subset
IM
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