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PMID: 15240818 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Oncostatin M-stimulated apical plasma membrane biogenesis requires p27(Kip1)-regulated cell cycle dynamics.

Molecular biology of the cell ·Vol. 15 ·No. 9 ·2004-09-00 ·Pages 4105-14

Van IJzendoorn SC, Théard D, Van Der Wouden JM, Visser W, Wojtal KA, Hoekstra D

Abstract

Oncostatin M regulates membrane traffic and stimulates apicalization of the cell surface in hepatoma cells in a protein kinase A-dependent manner. Here, we show that oncostatin M enhances the expression of the cyclin-dependent kinase (cdk)2 inhibitor p27(Kip1), which inhibits G(1)-S phase progression. Forced G(1)-S-phase transition effectively renders presynchronized cells insensitive to the apicalization-stimulating effect of oncostatin M. G(1)-S-phase transition prevents oncostatin M-mediated recruitment of protein kinase A to the centrosomal region and precludes the oncostatin M-mediated activation of a protein kinase A-dependent transport route to the apical surface, which exits the subapical compartment (SAC). This transport route has previously been shown to be crucial for apical plasma membrane biogenesis. Together, our data indicate that oncostatin M-stimulated apicalization of the cell surface is critically dependent on the ability of oncostatin M to control p27(Kip1)/cdk2-mediated G(1)-S-phase progression and suggest that the regulation of apical plasma membrane-directed traffic from SAC is coupled to centrosome-associated signaling pathways.

MeSH Terms
Cell Compartmentation Cell Cycle/physiology Cell Cycle Proteins/metabolism Cell Line Cell Membrane/drug effects,metabolism Cell Polarity Centrosome/metabolism Culture Media Cyclic AMP-Dependent Protein Kinases/metabolism Cyclin-Dependent Kinase Inhibitor p27 G1 Phase Hepatocytes/cytology,drug effects,metabolism Humans Membrane Lipids/metabolism Models, Biological Oncostatin M Peptides/pharmacology S Phase Signal Transduction Tumor Suppressor Proteins/metabolism
Chemicals
Cell Cycle Proteins Culture Media Membrane Lipids OSM protein, human Peptides Tumor Suppressor Proteins Oncostatin M Cyclin-Dependent Kinase Inhibitor p27 Cyclic AMP-Dependent Protein Kinases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Van IJzendoorn Sven C D
Department of Membrane Cell Biology, University of Groningen, 9713 AV, Groningen, The Netherlands. s.c.d.van.ijzendoorn@med.rug.nl
Théard Delphine
Van Der Wouden Johanna M
Visser Willy
Wojtal Kacper A
Hoekstra Dick
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Article Info
Journal
Molecular biology of the cell
Abbr.
Mol Biol Cell
ISSN
1059-1524
DOI
10.1091/mbc.e04-03-0201
Email
s.c.d.van.ijzendoorn@med.rug.nl
Published
2004-09-00
Epub
2004-00-07
Pages
4105-14
Language
English
Region
United States
NLM ID
9201390
PMCID
PMC515344
Subset
IM
External Links
PubMed source DOI: 10.1091/mbc.e04-03-0201 PMC Full Text View journal details
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