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PMID: 15187184 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

RegB/RegA, a highly conserved redox-responding global two-component regulatory system.

Microbiology and molecular biology reviews : MMBR ·Vol. 68 ·No. 2 ·2004-06-00 ·Pages 263-79

Elsen S, Swem LR, Swem DL, Bauer CE

Abstract

The Reg regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy-generating and energy-utilizing processes such as photosynthesis, carbon fixation, nitrogen fixation, hydrogen utilization, aerobic and anaerobic respiration, denitrification, electron transport, and aerotaxis. The redox signal that is detected by the membrane-bound sensor kinase, RegB, appears to originate from the aerobic respiratory chain, given that mutations in cytochrome c oxidase result in constitutive RegB autophosphorylation. Regulation of RegB autophosphorylation also involves a redox-active cysteine that is present in the cytosolic region of RegB. Both phosphorylated and unphosphorylated forms of the cognate response regulator RegA are capable of activating or repressing a variety of genes in the regulon. Highly conserved homologues of RegB and RegA have been found in a wide number of photosynthetic and nonphotosynthetic bacteria, with evidence suggesting that RegB/RegA plays a fundamental role in the transcription of redox-regulated genes in many bacterial species.

MeSH Terms
Amino Acid Sequence Conserved Sequence Gene Expression Regulation, Bacterial Genes, Bacterial Models, Biological Molecular Sequence Data Oxidation-Reduction Phosphorylation Photosynthetic Reaction Center Complex Proteins/metabolism Protein Kinases/chemistry,metabolism Protein Structure, Tertiary Regulon Rhodobacter capsulatus/genetics,metabolism Sequence Homology, Amino Acid
Chemicals
Photosynthetic Reaction Center Complex Proteins Protein Kinases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Elsen Sylvie
Laboratoire de Biochimie et de Biophysique des Systèmes Intégrés (UMR 5092 CNRS-CEA-UJF), Grenoble, France.
Swem Lee R
Swem Danielle L
Bauer Carl E
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.68.2.263-279.2004
Published
2004-06-00
Pages
263-79
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC419920
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040941 · United States
NIGMS NIH HHS · R37 GM040941 · United States
NIGMS NIH HHS · GM 40941 · United States
External Links
PubMed source DOI: 10.1128/MMBR.68.2.263-279.2004 PMC Full Text View journal details
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