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PMID: 15167810 Published · ppublish English Journal Article Review

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

The Biochemical journal ·Vol. 381 ·No. Pt 2 ·2004-07-15 ·Pages 329-42

Mackintosh C

Abstract

14-3-3 proteins exert an extraordinarily widespread influence on cellular processes in all eukaryotes. They operate by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. In these ways, 14-3-3s 'finish the job' when phosphorylation alone lacks the power to drive changes in the activities of intracellular proteins. By interacting dynamically with phosphorylated proteins, 14-3-3s often trigger events that promote cell survival--in situations from preventing metabolic imbalances caused by sudden darkness in leaves to mammalian cell-survival responses to growth factors. Recent work linking specific 14-3-3 isoforms to genetic disorders and cancers, and the cellular effects of 14-3-3 agonists and antagonists, indicate that the cellular complement of 14-3-3 proteins may integrate the specificity and strength of signalling through to different cellular responses.

MeSH Terms
14-3-3 Proteins/chemistry,metabolism Animals Cell Physiological Phenomena Humans Phosphoproteins/chemistry,metabolism Protein Interaction Mapping Protein Structure, Quaternary/physiology
Chemicals
14-3-3 Proteins Phosphoproteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mackintosh Carol
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK. c.mackintosh@dundee.ac.uk
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
1470-8728
DOI
10.1042/BJ20031332
Email
c.mackintosh@dundee.ac.uk
Published
2004-07-15
Pages
329-42
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1133837
Subset
IM
External Links
PubMed source DOI: 10.1042/BJ20031332 PMC Full Text View journal details
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