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PMID: 11606630 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Conditional rescue of olfactory learning and memory defects in mutants of the 14-3-3zeta gene leonardo.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 21 ·No. 21 ·2001-11-01 ·Pages 8417-25

Philip N, Acevedo SF, Skoulakis EM

Abstract

Members of the ubiquitous 14-3-3 family of proteins are abundantly expressed in metazoan neurons. The Drosophila 14-3-3zeta gene leonardo is preferentially expressed in adult mushroom bodies, centers of insect learning and memory. Mutants exhibit defects in olfactory learning and memory and physiological neuroplasticity at the neuromuscular junction. Because strong mutations in this gene are lethal, we investigated the nature of the defects that precipitate the learning and memory deficit and the role of the two protein isoforms encoded by leonardo in these processes. We find that the behavioral deficit in the mutants is not caused by aberrant development, LEONARDO protein is acutely required for learning and memory, and both protein isoforms can function equivalently in embryonic development and behavioral neuroplasticity.

MeSH Terms
14-3-3 Proteins Alleles Animals Behavior, Animal/physiology Conditioning, Psychological/physiology Drosophila Ganglia, Invertebrate/metabolism Gene Expression Regulation/physiology Gene Transfer, Horizontal Genes, Lethal Learning/physiology Memory/physiology Memory Disorders/genetics Mutation Neuronal Plasticity/physiology Phenotype Smell/physiology Stimulation, Chemical Transgenes Tyrosine 3-Monooxygenase/genetics,metabolism
Chemicals
14-3-3 Proteins Tyrosine 3-Monooxygenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Philip N
Department of Biology and Program in Genetics, Texas A&M University, College Station, Texas 77843-2475, USA.
Acevedo S F
Skoulakis E M
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2001-11-01
Pages
8417-25
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6762794
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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