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PMID: 14977192 Published · ppublish English Journal Article Review

Mitochondrial morphology is dynamic and varied.

Molecular and cellular biochemistry ·Vol. 256-257 ·No. 1-2 ·2004-00-00 ·Pages 331-9

Rube DA, van der Bliek AM

Abstract

The morphology of mitochondria is dynamic, often changing within a cell and from one cell type to the next. In the past few years, significant advances have been made in the study of mechanisms that help determine the morphologies of mitochondria and their intracellular distributions. It has become apparent that the distribution of mitochondria is determined by movement along the cytoskeleton, driven by molecular motors, and attachment to the cytoskeleton, using specific connector proteins. However, not all cells use the same cytoskeletal elements and motor proteins for mitochondrial movement and attachment. The shapes of mitochondria are also influenced by the extent of mitochondrial division and fusion. A number of proteins that affect mitochondrial division and fusion were recently discovered. Here, we review the proteins involved in the distribution and morphology of mitochondria and discuss how they may be physiologically regulated.

MeSH Terms
Apoptosis Mitochondria/genetics,physiology,ultrastructure
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rube Daniel A
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
van der Bliek Alexander M
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1023/b:mcbi.0000009879.01256.f6
Published
2004-00-00
Pages
331-9
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1023/b:mcbi.0000009879.01256.f6 View journal details
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