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PMID: 14660734 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mechanisms for pituitary tumorigenesis: the plastic pituitary.

The Journal of clinical investigation ·Vol. 112 ·No. 11 ·2003-12-00 ·Pages 1603-18

Melmed S

Abstract

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising from functional pituitary cells. Discussed herein are the mechanisms underlying hereditary pituitary hypoplasia, reversible pituitary hyperplasia, excess hormone production, and tumor initiation and promotion associated with normal and abnormal pituitary differentiation in health and disease.

MeSH Terms
Adenoma/etiology,pathology Animals Chromosomal Instability Estrogens/physiology Genes, Tumor Suppressor/physiology Humans Hyperplasia Hypothalamus/physiology Loss of Heterozygosity Multiple Endocrine Neoplasia/etiology Neoplasm Proteins/physiology Pituitary Gland/pathology,physiology Pituitary Neoplasms/etiology,genetics,pathology Securin
Chemicals
Estrogens Neoplasm Proteins Securin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Melmed Shlomo
Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048, USA. melmed@csmc.edu
References (140)
140 references, click to expand
  1. Normal pituitary hypertrophy as a frequent cause of pituitary incidentaloma: a follow-up study.
    J Clin Endocrinol Metab. 2001 Jul;86(7):3009-15 PMID: 11443160
  2. Tbx19, a tissue-selective regulator of POMC gene expression.
    Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8674-9 PMID: 11447259
  3. Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment.
    J Clin Endocrinol Metab. 2001 Aug;86(8):3809-14 PMID: 11502816
  4. Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors.
    J Clin Endocrinol Metab. 2001 Aug;86(8):3989-95 PMID: 11502843
  5. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.
    Science. 2001 Aug 17;293(5533):1320-3 PMID: 11509732
  6. Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation.
    J Clin Endocrinol Metab. 2001 Sep;86(9):4353-7 PMID: 11549674
  7. Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4.
    Am J Hum Genet. 2001 Nov;69(5):961-8 PMID: 11567216
  8. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division.
    Mol Endocrinol. 2001 Nov;15(11):1870-9 PMID: 11682618
  9. Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor.
    J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6 PMID: 11701737
  10. Genesis of pituitary adenomas: state of the art.
    J Neurooncol. 2001 Sep;54(2):95-110 PMID: 11761437
  11. Dual inhibition of sister chromatid separation at metaphase.
    Cell. 2001 Dec 14;107(6):715-26 PMID: 11747808
  12. Derivation of human tumor cells in vitro without widespread genomic instability.
    Cancer Res. 2001 Dec 15;61(24):8838-44 PMID: 11751406
  13. p53 gene mutations in pituitary adenomas: rare events.
    Clin Endocrinol (Oxf). 1994 Dec;41(6):809-14 PMID: 7889618
  14. Familial prolactinoma.
    Clin Endocrinol (Oxf). 1995 May;42(5):483-6 PMID: 7621566
  15. Parity and pituitary adenoma risk.
    J Natl Cancer Inst. 1995 Sep 20;87(18):1410-1 PMID: 7658503
  16. Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas.
    Endocrinology. 1995 Oct;136(10):4479-88 PMID: 7664668
  17. The cyclic adenosine 3',5'-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas.
    Mol Endocrinol. 1995 Jul;9(7):777-83 PMID: 7476961
  18. Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription.
    J Clin Invest. 1996 Jan 1;97(1):187-95 PMID: 8550832
  19. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
    Cell. 1996 May 31;85(5):721-32 PMID: 8646780
  20. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
    Cell. 1996 May 31;85(5):733-44 PMID: 8646781
  21. p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions.
    Neurosurgery. 1996 Apr;38(4):765-70; discussion 770-1 PMID: 8692397
  22. Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors.
    Int J Cancer. 1996 Jul 3;67(1):16-9 PMID: 8690518
  23. Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas.
    Clin Endocrinol (Oxf). 1996 Mar;44(3):341-7 PMID: 8729534
  24. Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex).
    J Clin Endocrinol Metab. 1996 Oct;81(10):3607-14 PMID: 8855810
  25. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
    Nature. 1996 Nov 28;384(6607):327-33 PMID: 8934515
  26. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome.
    Nat Genet. 1996 Dec;14(4):392-9 PMID: 8944018
  27. Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice.
    Endocrinology. 1999 Nov;140(11):5348-55 PMID: 10537166
  28. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis.
    Nat Med. 1999 Nov;5(11):1317-21 PMID: 10546001
  29. Transfection of an inducible p16/CDKN2A construct mediates reversible growth inhibition and G1 arrest in the AtT20 pituitary tumor cell line.
    Mol Endocrinol. 1999 Nov;13(11):1801-10 PMID: 10551774
  30. Pituitary magnetic resonance imaging and function in patients with growth hormone deficiency with and without mutations in GHRH-R, GH-1, or PROP-1 genes.
    J Clin Endocrinol Metab. 2002 Nov;87(11):5076-84 PMID: 12414875
  31. p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development.
    Oncogene. 2003 Jan 23;22(3):361-9 PMID: 12545157
  32. Coordinated regulation of life and death by RB.
    Nat Rev Cancer. 2003 Feb;3(2):130-8 PMID: 12563312
  33. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1034-9 PMID: 12552124
  34. Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour.
    Clin Endocrinol (Oxf). 2003 Feb;58(2):141-50 PMID: 12580928
  35. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.
    Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3428-32 PMID: 12626748
  36. Tpit determines alternate fates during pituitary cell differentiation.
    Genes Dev. 2003 Mar 15;17(6):738-47 PMID: 12651892
  37. Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression.
    Mol Endocrinol. 2003 Apr;17(4):600-9 PMID: 12554778
  38. Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors.
    J Clin Endocrinol Metab. 2002 Sep;87(9):4238-44 PMID: 12213878
  39. Senescence, apoptosis and therapy--cutting the lifelines of cancer.
    Nat Rev Cancer. 2003 Apr;3(4):286-95 PMID: 12671667
  40. Giant prolactinomas in men: efficacy of cabergoline treatment.
    Clin Endocrinol (Oxf). 2003 May;58(5):662-70 PMID: 12699451
  41. Isolation and characterization of a pituitary tumor-transforming gene (PTTG).
    Mol Endocrinol. 1997 Apr;11(4):433-41 PMID: 9092795
  42. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors.
    J Clin Invest. 1997 Nov 1;100(9):2386-92 PMID: 9410919
  43. Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
    Cancer Res. 1997 Dec 15;57(24):5446-51 PMID: 9407947
  44. Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese.
    J Clin Endocrinol Metab. 1998 Mar;83(3):960-5 PMID: 9506756
  45. Prolactinomas express human heparin-binding secretory transforming gene (hst) protein product: marker of tumour invasiveness.
    Clin Endocrinol (Oxf). 1998 Jan;48(1):23-9 PMID: 9509064
  46. Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
    J Clin Endocrinol Metab. 1998 May;83(5):1624-8 PMID: 9589667
  47. Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse.
    Nat Genet. 1998 Jun;19(2):125-33 PMID: 9620767
  48. hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias.
    Oncogene. 1999 Sep 23;18(39):5473-6 PMID: 10498901
  49. Low expression of the cell cycle inhibitor p27Kip1 in normal corticotroph cells, corticotroph tumors, and malignant pituitary tumors.
    J Clin Endocrinol Metab. 1999 Oct;84(10):3823-30 PMID: 10523037
  50. Absence of activating mutations in the GnRH receptor gene in human pituitary gonadotroph adenomas.
    Eur J Endocrinol. 1998 Aug;139(2):157-60 PMID: 9724070
  51. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.
    Genes Dev. 1998 Sep 15;12(18):2899-911 PMID: 9744866
  52. Differential expression of estrogen receptor-beta (ER beta) in human pituitary tumors: functional interactions with ER alpha and a tumor-specific splice variant.
    J Clin Endocrinol Metab. 1998 Sep;83(9):3308-15 PMID: 9745446
  53. Galanin regulates prolactin release and lactotroph proliferation.
    Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12671-6 PMID: 9770544
  54. Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.
    Oncogene. 2000 Jan 20;19(3):403-9 PMID: 10656688
  55. Transdifferentiation of somatotrophs to thyrotrophs in the pituitary of patients with protracted primary hypothyroidism.
    Virchows Arch. 2000 Jan;436(1):43-51 PMID: 10664161
  56. Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12.
    J Clin Endocrinol Metab. 2000 Feb;85(2):707-14 PMID: 10690880
  57. Expression of pituitary-tumour transforming gene in colorectal tumours.
    Lancet. 2000 Feb 26;355(9205):716-9 PMID: 10703804
  58. Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas.
    Clin Endocrinol (Oxf). 2000 Jan;52(1):35-42 PMID: 10651751
  59. Angiogenesis in pituitary adenomas - relationship to endocrine function, treatment and outcome.
    J Endocrinol. 2000 May;165(2):475-81 PMID: 10810311
  60. Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.
    Nat Genet. 2000 Jun;25(2):182-6 PMID: 10835633
  61. Sporadic pituitary tumours: from epidemiology to use of databases.
    Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Oct;13(3):451-60 PMID: 10909435
  62. Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging.
    Mol Endocrinol. 2000 Aug;14(8):1137-46 PMID: 10935539
  63. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
    Nat Genet. 2000 Sep;26(1):89-92 PMID: 10973256
  64. Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
    J Clin Invest. 2000 Sep;106(5):R31-8 PMID: 10974026
  65. Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function.
    J Biol Chem. 2000 Oct 6;275(40):31191-8 PMID: 10906323
  66. Pituitary hyperplasia.
    Pituitary. 1999 May;1(3-4):169-79 PMID: 11081195
  67. Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis.
    J Biol Chem. 2000 Nov 24;275(47):36502-5 PMID: 11013229
  68. Pituitary-adrenal axis regulation in CRH-deficient mice.
    Endocr Res. 2000 Nov;26(4):1057-66 PMID: 11196416
  69. Reversible transdifferentiation: interconversion of somatotrophs and lactotrophs in pituitary hyperplasia.
    Mod Pathol. 2001 Jan;14(1):20-8 PMID: 11211306
  70. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.
    EMBO J. 2001 Feb 15;20(4):792-801 PMID: 11179223
  71. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.
    Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23 PMID: 11158604
  72. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins.
    Cell. 2001 Mar 23;104(6):849-59 PMID: 11290323
  73. Absence of mutations in the growth hormone (GH)-releasing hormone receptor gene in GH-secreting pituitary adenomas.
    Clin Endocrinol (Oxf). 2001 Mar;54(3):301-7 PMID: 11298081
  74. Securin is required for chromosomal stability in human cells.
    Cell. 2001 May 18;105(4):445-57 PMID: 11371342
  75. Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility.
    Hum Mol Genet. 2001 May 15;10(11):1141-53 PMID: 11371507
  76. Oncogene activation in pituitary tumors.
    Brain Pathol. 2001 Jul;11(3):328-41 PMID: 11414475
  77. Proliferation and differentiation of rat anterior pituitary cells.
    Anat Embryol (Berl). 2002 Dec;206(1-2):1-11 PMID: 12478362
  78. A molecular signature of metastasis in primary solid tumors.
    Nat Genet. 2003 Jan;33(1):49-54 PMID: 12469122
  79. Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice.
    Nat Med. 1996 Dec;2(12):1316-21 PMID: 8946829
  80. Long-term follow-up of patients with hyperprolactinaemia.
    Clin Endocrinol (Oxf). 1996 Sep;45(3):299-303 PMID: 8949567
  81. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker.
    J Clin Endocrinol Metab. 1997 Mar;82(3):818-24 PMID: 9062489
  82. Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors.
    J Clin Endocrinol Metab. 1998 Nov;83(11):3965-72 PMID: 9814476
  83. The cytogenesis and pathogenesis of pituitary adenomas.
    Endocr Rev. 1998 Dec;19(6):798-827 PMID: 9861546
  84. Genetic instabilities in human cancers.
    Nature. 1998 Dec 17;396(6712):643-9 PMID: 9872311
  85. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).
    Mol Endocrinol. 1999 Jan;13(1):156-66 PMID: 9892021
  86. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas.
    J Clin Endocrinol Metab. 1999 Feb;84(2):761-7 PMID: 10022450
  87. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing.
    J Biol Chem. 1999 May 14;274(20):13886-93 PMID: 10318797
  88. Prop-1 gene expression in human pituitary tumors.
    J Clin Endocrinol Metab. 1999 Jul;84(7):2581-4 PMID: 10404841
  89. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.
    Science. 1999 Jul 16;285(5426):418-22 PMID: 10411507
  90. Detection of chromosomal imbalances in growth hormone-secreting pituitary tumors by comparative genomic hybridization.
    Hum Pathol. 1999 Sep;30(9):1019-23 PMID: 10492035
  91. Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis.
    J Clin Invest. 2002 Jan;109(1):69-78 PMID: 11781352
  92. Functional role of estrogen in pituitary tumor pathogenesis.
    J Clin Invest. 2002 Jan;109(2):277-83 PMID: 11805140
  93. Pseudotumor of the pituitary due to PROP-1 deletion.
    J Pediatr Endocrinol Metab. 2002 Jan;15(1):95-101 PMID: 11822586
  94. Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.
    J Clin Endocrinol Metab. 2002 Feb;87(2):457-65 PMID: 11836268
  95. Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis.
    J Clin Endocrinol Metab. 2002 Mar;87(3):1262-7 PMID: 11889197
  96. Development of gonadotropes may involve cyclic transdifferentiation of growth hormone cells.
    Arch Physiol Biochem. 2002 Apr;110(1-2):42-9 PMID: 11935399
  97. Perspective: genetic and genomic approaches in elucidating mechanisms of pituitary development.
    Endocrinology. 2002 Jun;143(6):2007-11 PMID: 12021162
  98. Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4.
    Endocrinology. 2002 Aug;143(8):3001-8 PMID: 12130566
  99. Segregating sister genomes: the molecular biology of chromosome separation.
    Science. 2002 Jul 26;297(5581):559-65 PMID: 12142526
  100. Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia.
    Endocr Pathol. 2002 Summer;13(2):157-65 PMID: 12165665
  101. Molecular basis of combined pituitary hormone deficiencies.
    Endocr Rev. 2002 Aug;23(4):431-42 PMID: 12202459
  102. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.
    Nat Genet. 2002 Oct;32(2):306-11 PMID: 12355087
  103. Primary medical therapy for acromegaly: an open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on growth hormone, insulin-like growth factor-I, and tumor size.
    J Clin Endocrinol Metab. 2002 Oct;87(10):4554-63 PMID: 12364434
  104. Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms.
    J Clin Invest. 2002 Oct;110(7):973-81 PMID: 12370275
  105. Pituitary tumorigenesis in prolactin gene-disrupted mice.
    Endocrinology. 2002 Nov;143(11):4429-36 PMID: 12399440
  106. Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas.
    Nat Med. 2002 Nov;8(11):1281-7 PMID: 12379847
  107. Differential expression of galectin-3 in pituitary tumors.
    Cancer Res. 2003 May 1;63(9):2251-5 PMID: 12727847
  108. PPAR-gamma receptor ligands: novel therapy for pituitary adenomas.
    J Clin Invest. 2003 May;111(9):1381-8 PMID: 12727930
  109. Genome-wide amplification and allelotyping of sporadic pituitary adenomas identify novel regions of genetic loss.
    Genes Chromosomes Cancer. 2003 Jul;37(3):225-36 PMID: 12759921
  110. Molecular defects in the pathogenesis of pituitary tumours.
    Front Neuroendocrinol. 2003 Apr;24(2):94-127 PMID: 12763000
  111. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells.
    Endocrinology. 2003 Nov;144(11):4991-8 PMID: 12960092
  112. Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor.
    J Clin Invest. 1982 Nov;70(5):965-77 PMID: 6290540
  113. Phenotypic switching in GH3 rat pituitary tumor cells: linked expression of growth hormone and another hormonally responsive protein.
    DNA. 1983;2(2):113-20 PMID: 6872825
  114. Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. A clinical, morphologic, and biochemical study.
    N Engl J Med. 1984 Jul 5;311(1):13-20 PMID: 6328303
  115. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription.
    Nature. 1985 Mar 21-27;314(6008):279-81 PMID: 2858817
  116. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.
    Proc Natl Acad Sci U S A. 1986 Sep;83(18):6854-7 PMID: 3018748
  117. Pathology of growth hormone-producing tumors of the human pituitary.
    Semin Diagn Pathol. 1986 Feb;3(1):18-33 PMID: 3303228
  118. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
    Nature. 1987 Dec 10-16;330(6148):566-8 PMID: 2825031
  119. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene.
    Mol Endocrinol. 1988 Jul;2(7):606-12 PMID: 3137455
  120. Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations.
    Endocr Rev. 1988 Aug;9(3):357-73 PMID: 3145190
  121. The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases.
    Mayo Clin Proc. 1990 Apr;65(4):461-74 PMID: 2159093
  122. Clinically nonfunctioning pituitary tumors are monoclonal in origin.
    J Clin Invest. 1990 Jul;86(1):336-40 PMID: 1973174
  123. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.
    Nature. 1990 Oct 11;347(6293):528-33 PMID: 1977085
  124. Clonal origin of pituitary adenomas.
    J Clin Endocrinol Metab. 1990 Dec;71(6):1427-33 PMID: 1977759
  125. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant.
    Nature. 1991 Apr 18;350(6319):622-4 PMID: 1826763
  126. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
    N Engl J Med. 1991 Dec 12;325(24):1688-95 PMID: 1944469
  127. Transforming DNA sequences present in human prolactin-secreting pituitary tumors.
    Mol Endocrinol. 1991 Nov;5(11):1687-95 PMID: 1779971
  128. Pituitary hyperplasia induced by ectopic expression of nerve growth factor.
    Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2764-8 PMID: 1348359
  129. Effects of an Rb mutation in the mouse.
    Nature. 1992 Sep 24;359(6393):295-300 PMID: 1406933
  130. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone.
    Endocrinology. 1992 Nov;131(5):2083-9 PMID: 1425411
  131. Pituitary tumors in mice exposed prenatally to diethylstilbestrol.
    Cancer Res. 1993 Apr 1;53(7):1546-9 PMID: 8453621
  132. Molecular basis of the little mouse phenotype and implications for cell type-specific growth.
    Nature. 1993 Jul 15;364(6434):208-13 PMID: 8391647
  133. Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors.
    J Clin Endocrinol Metab. 1994 Mar;78(3):568-74 PMID: 7907340
  134. H-ras mutations in human pituitary carcinoma metastases.
    J Clin Endocrinol Metab. 1994 Apr;78(4):842-6 PMID: 8157709
  135. Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.
    J Clin Endocrinol Metab. 1994 Apr;78(4):922-7 PMID: 8157722
  136. Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study.
    Arch Pathol Lab Med. 1994 May;118(5):562-5 PMID: 8192565
  137. Pit-1 gene expression in the human pituitary and pituitary adenomas.
    J Clin Endocrinol Metab. 1994 Jul;79(1):189-96 PMID: 8027225
  138. c-myc, c-fos, and c-myb gene expression in human pituitary adenomas.
    J Clin Endocrinol Metab. 1994 Jul;79(1):253-7 PMID: 8027238
  139. Loss of heterozygosity at the retinoblastoma locus in human pituitary tumors.
    Cancer. 1994 Jul 15;74(2):693-6 PMID: 8033049
  140. Age-related and gender-related occurrence of pituitary adenomas.
    Clin Endocrinol (Oxf). 1994 Sep;41(3):359-64 PMID: 7893282
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI20401
Email
melmed@csmc.edu
Published
2003-12-00
Pages
1603-18
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC281651
Subset
IM
Grants
NCI NIH HHS · R01 CA075979 · United States
NIDDK NIH HHS · R01 DK064169 · United States
NCI NIH HHS · CA75979 · United States
NIDDK NIH HHS · DK64169 · United States
External Links
PubMed source DOI: 10.1172/JCI20401 PMC Full Text View journal details
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