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PMID: 14617746 Published · ppublish English Journal Article

The application of biofilm science to the study and control of chronic bacterial infections.

The Journal of clinical investigation ·Vol. 112 ·No. 10 ·2003-11-00 ·Pages 1466-77

Costerton W, Veeh R, Shirtliff M, Pasmore M, Post C, Ehrlich G

Abstract

Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.

MeSH Terms
Bacteria/metabolism,ultrastructure Bacterial Infections/immunology,microbiology,therapy Bacterial Physiological Phenomena Biofilms Chronic Disease Cross Infection/immunology,microbiology,therapy Epithelial Cells/cytology,immunology,metabolism,microbiology Equipment Contamination Humans Neutrophils/immunology,metabolism Prosthesis-Related Infections/immunology,microbiology,therapy
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Costerton William
Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717-3980, USA. bill_c@erc.montana.edu
Veeh Richard
Shirtliff Mark
Pasmore Mark
Post Christopher
Ehrlich Garth
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI20365
Email
bill_c@erc.montana.edu
Published
2003-11-00
Pages
1466-77
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC259139
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1172/JCI20365 PMC Full Text View journal details
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