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PMID: 12732311 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

LuxS quorum sensing: more than just a numbers game.

Current opinion in microbiology ·Vol. 6 ·No. 2 ·2003-04-00 ·Pages 191-7

Xavier KB, Bassler BL

Abstract

Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extracellular signaling molecules called autoinducers. Quorum sensing allows populations of bacteria to collectively control gene expression, and thus synchronize group behavior. Processes controlled by quorum sensing are typically ones that are unproductive unless many bacteria act together. Most autoinducers enable intraspecies communication; however, a recently discovered autoinducer AI-2 has been proposed to serve as a 'universal signal' for interspecies communication. Studies suggest that AI-2 encodes information in addition to specifics about cell number.

MeSH Terms
Bacteria/classification,genetics,metabolism Bacterial Physiological Phenomena Bacterial Proteins/genetics,physiology Carbon-Sulfur Lyases Gene Expression Regulation, Bacterial Homoserine/analogs & derivatives,biosynthesis,chemistry,physiology Lactones/chemistry Models, Biological Models, Molecular Signal Transduction
Chemicals
Bacterial Proteins Lactones N-octanoylhomoserine lactone Homoserine Carbon-Sulfur Lyases LuxS protein, Bacteria
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Xavier Karina B
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.
Bassler Bonnie L
Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1369-5274
Published
2003-04-00
Pages
191-7
Language
English
Region
England
NLM ID
9815056
Subset
IM
Grants
NIGMS NIH HHS · GM65859 · United States
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