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PMID: 14610288 Published · ppublish English Journal Article Review

Human genetics of common mycobacterial infections.

Immunologic research ·Vol. 28 ·No. 2 ·2003-00-00 ·Pages 109-29

Remus N, Alcaïs A, Abel L

Abstract

There is increasing interest in and understanding of the role of human genetic factors controlling susceptibility/resistance to infectious diseases. This is of particular importance for the two most common mycobacterial infections, tuberculosis and leprosy, because this will allow a genetic dissection of antimycobacterial immunity and should open new fields of preventive and therapeutic measures. In this review we will initially discuss various methods of genetic epidemiology that have been and are being developed to identify human genes controlling infectious diseases, and then illustrate the findings obtained in the numerous studies performed in tuberculosis and leprosy. Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established.

MeSH Terms
Cation Transport Proteins/genetics Genetic Linkage Genetic Predisposition to Disease/epidemiology HLA-DR2 Antigen/genetics Humans Laminin/genetics,metabolism Leprosy/genetics Major Histocompatibility Complex/genetics,immunology Mannose-Binding Lectin/genetics,immunology,metabolism Receptors, Calcitriol/genetics,immunology,metabolism Tuberculosis/genetics
Chemicals
Cation Transport Proteins HLA-DR2 Antigen Laminin Mannose-Binding Lectin Receptors, Calcitriol laminin alpha 2 natural resistance-associated macrophage protein 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Remus Natascha
Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, Paris, France.
Alcaïs Alexandre
Abel Laurent
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:28:2:109
Published
2003-00-00
Pages
109-29
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1385/IR:28:2:109 View journal details
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