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PMID: 8600387 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A comprehensive genetic map of the human genome based on 5,264 microsatellites.

Nature ·Vol. 380 ·No. 6570 ·1996-03-14 ·Pages 152-4

Dib C, Fauré S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J

Abstract

The great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites. We report here the last version of the Généthon human linkage map. This map consists of 5,264 short tandem (AC/TG)n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.

MeSH Terms
Algorithms Chromosome Mapping Chromosomes, Human, Pair 22 Genetic Linkage Genome, Human Genotype Humans Microsatellite Repeats Molecular Sequence Data
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Dib C
Généthon and CNRS URA 1922, Evry, France.
Fauré S
Fizames C
Samson D
Drouot N
Vignal A
Millasseau P
Marc S
Hazan J
Seboun E
Lathrop M
Gyapay G
Morissette J
Weissenbach J
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/380152a0
Published
1996-03-14
Pages
152-4
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
Z50876, Z50877, Z50878, Z50879, Z50880, Z50881, Z50882, Z50883, Z50884, Z50885, Z50886, Z50887, Z50888, Z50889, Z50890, Z50891, Z50892, Z50893, Z50894, Z50895, Z50896, Z50897, Z50898, Z50899, Z50900, Z50901, Z50902, Z50903, Z50904, Z50905
Corrections
CommentIn
PMID: 8600381
External Links
PubMed source DOI: 10.1038/380152a0 View journal details
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