Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever.

The Journal of experimental medicine ·Vol. 114 ·1961-11-01 ·Pages 729-39

GILLMAN SM, BORNSTEIN DL, WOOD WB

Abstract

Rabbits made granulocytopenic with nitrogen mustard have been shown to generate serum endogenous pyrogen when given a fever-producing dose of bacterial endotoxin. This finding is in accord with the hypothesis that endogenous pyrogen plays a central role in the pathogenesis of endotoxin fever. The fact that leucopenic animals produce less serum-endogenous pyrogen than normal animals given the same dose of endotoxin has also been confirmed and suggests that polymorphonuclear leucocytes constitute a major source of the endogenous pyrogen which is demonstrable in the circulation during endotoxin fever.

Keywords

FEVER/experimental PYROGENS/blood TOXINS AND ANTITOXINS/pharmacology

MeSH Terms

Animals Antitoxins/pharmacology Endotoxins Fever Interleukin-1 Leukocytes Pyrogens/blood Rabbits Toxins, Biological/pharmacology

Chemicals

Antitoxins Endotoxins Interleukin-1 Pyrogens Toxins, Biological leukocyte endogenous mediator

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

GILLMAN S M

BORNSTEIN D L

WOOD W B

References (26)

26 references, click to expand

Influence of nitrogen mustard upon reactions to bacterial endotoxins; Shwartzman phenomenon and fever.
Proc Soc Exp Biol Med. 1952 Oct;81(1):304-7 PMID: 13047394
Studies of the effect of bacterial endotoxins on rabbit leucocytes. I. Effect of intravenous injection of the substances with and without induction of the local Shwartzman reaction.
J Exp Med. 1953 Oct;98(4):331-48 PMID: 13096659
Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.
J Exp Med. 1953 Nov;98(5):493-508 PMID: 13109105
Some humoral aspects of the development of tolerance to bacterial pyrogens in rabbits.
Am J Physiol. 1954 May;177(2):269-78 PMID: 13158559
The effect of hydrocortisone and of piromen in vitro on leukocytes of patients receiving ACTH and cortisone therapy.
J Clin Invest. 1954 May;33(5):725-31 PMID: 13163161
Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.
J Exp Med. 1955 Nov 1;102(5):499-516 PMID: 13271667
Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.
J Exp Med. 1957 Aug 1;106(2):293-314 PMID: 13449238
Studies on the pathogenesis of fever. IX. Characteristics of endogenous serum pyrogen and mechanisms governing its release.
J Exp Med. 1957 Dec 1;106(6):787-809 PMID: 13481245
Studies on the pathogenesis of fever. III. The leucocytic origin of endogenous pyrogen in acute inflammatory exudates.
J Exp Med. 1958 Feb 1;107(2):279-89 PMID: 13491762
Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.
J Exp Med. 1958 Feb 1;107(2):291-303 PMID: 13491763
Studies on the pathogenesis of fever. V. The relation of circulating endogenous pyrogen to the fever of acute bacterial infections.
J Exp Med. 1958 Feb 1;107(2):305-18 PMID: 13491764
Pathogenesis of fever: evidence for direct cerebral action of bacterial endotoxins.
Trans Assoc Am Physicians. 1957;70:64-73 PMID: 13496115
Studies on the pathogenesis of fever with influenzal viruses. I. The appearance of an endogenous pyrogen in the blood following intravenous injection of virus.
J Exp Med. 1958 Mar 1;107(3):383-401 PMID: 13513908
Studies on the pathogenesis of fever with influenzal viruses. II. The effects of endogenous pyrogen in normal and virus-tolerant recipients.
J Exp Med. 1958 Mar 1;107(3):403-14 PMID: 13513909
Studies on the pathogenesis of fever with influenzal viruses. III. The relation of tolerance to the production of endogenous pyrogen.
J Exp Med. 1958 Mar 1;107(3):415-35 PMID: 13513910
Bacterial pyrogens.
Pharmacol Rev. 1957 Dec;9(4):427-79 PMID: 13517946
Studies on the cause of fever.
N Engl J Med. 1958 May 22;258(21):1023-31 PMID: 13552914
Studies on tuberculin fever. I. The mechanism of fever in tuberculin hypersensitivity.
J Exp Med. 1959 Apr 1;109(4):339-59 PMID: 13641561
The experimental approach to the mechanism of fever.
AMA Arch Intern Med. 1959 Jun;103(6):991-1001 PMID: 13649005
Further studies on passive transfer of tolerance to pyrogenicity of bacterial endotoxin. The febrile and leucopenic responses.
J Exp Med. 1960 Oct 1;112:619-34 PMID: 13701608
Observations on the pyrogenic response and its application to the bioassay of endotoxin.
J Clin Invest. 1961 Feb;40:295-301 PMID: 13752168
Pathogenesis of fever.
Physiol Rev. 1960 Jul;40:580-646 PMID: 13794961
Studies on the pathogenesis of fever. VI. The interaction of leucocytes and endotoxin in vitro.
J Exp Med. 1959 Dec 1;110:1005-16 PMID: 13811296
Fever: pathogenesis and circulatory changes.
Circulation. 1959 Dec;20:1133-42 PMID: 13812670
Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine.
J Exp Med. 1955 May 1;101(5):519-28 PMID: 14367676
Studies with radioactive endotoxin. II. Correlation of physiologic effects with distribution of radioactivity in rabbits injected with radioactive sodium chromate.
J Clin Invest. 1955 Jun;34(6):858-66 PMID: 14381515

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.114.5.729

Published

1961-11-01

Pages

729-39

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180372

Subset

External Links

PubMed source DOI: 10.1084/jem.114.5.729 PMC Full Text View journal details

Analysis Services

Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever.

Contact

WeChat Official Account