Studies on the pathogenesis of fever. IX. Characteristics of endogenous serum pyrogen and mechanisms governing its release.
The "endogenous serum pyrogen" that appears in the circulating blood after a single intravenous injection of endotoxin does not produce leukopenia in normal animals, fails to provoke the local Shwartzman reaction, and elicits no "tolerance" when injected daily. Suppression of the febrile response to endotoxin by prednisone does not prevent the appearance of pyrogen in the blood. Animals given large amounts of endotoxin daily continue to respond with high fevers despite failure of endogenous serum pyrogen to appear in detectable amounts after the first two or three injections. Analysis of the response to daily injections shows clearly that the fever during the first 2 hours after administration of endotoxin is unrelated to levels of endogenous serum pyrogen; in contrast, the magnitude of the fever after the 2nd hour correlates well with endogenous pyrogen in some instances. The leukopenic response to endotoxin could not be correlated with the appearance of endogenous serum pyrogen. The differences between endotoxin and endogenous pyrogen and the similarities between leukocyte extracts (sterile exudates) and endogenous pyrogen are summarized and discussed. Dissociation of the febrile response to bacterial endotoxin and levels of endogenous serum pyrogen are discussed and it is concluded that a mechanism involving both direct and indirect action of endotoxins offers the best explanation for the pyrogenic action of these bacterial products.
18 references, click to expand
-
Latency of pyrogen fever; appearance of a fast-acting pyrogen in the blood of febrile animals and in plasma incubated with bacterial pyrogen.Am J Physiol. 1953 Apr;173(1):47-54 PMID: 13050758
-
Studies of the effect of bacterial endotoxins on rabbit leucocytes. I. Effect of intravenous injection of the substances with and without induction of the local Shwartzman reaction.J Exp Med. 1953 Oct;98(4):331-48 PMID: 13096659
-
The effect of cortisone upon reactions of rabbits to bacterial endotoxins with particular reference to acquired resistance.Bull Johns Hopkins Hosp. 1953 Nov;93(5):290-308 PMID: 13106583
-
Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.J Exp Med. 1953 Nov;98(5):477-92 PMID: 13109104
-
Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.J Exp Med. 1953 Nov;98(5):493-508 PMID: 13109105
-
The effect of hydrocortisone and of piromen in vitro on leukocytes of patients receiving ACTH and cortisone therapy.J Clin Invest. 1954 May;33(5):725-31 PMID: 13163161
-
Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.J Exp Med. 1955 Nov 1;102(5):499-516 PMID: 13271667
-
Studies on the pathogenesis of fever. VI. The effect of heat on endogenous and exogenous pyrogen in the serum of dogs.Bull Johns Hopkins Hosp. 1957 May;100(5):197-208 PMID: 13436926
-
Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.Bull Johns Hopkins Hosp. 1957 Jun;100(6):277-86 PMID: 13436930
-
Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.J Exp Med. 1957 Aug 1;106(2):293-314 PMID: 13449238
-
Studies on the antipyretic action of cortisone in pyrogen-induced fever.J Exp Med. 1955 Apr 1;101(4):353-66 PMID: 14354106
-
Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine.J Exp Med. 1955 May 1;101(5):519-28 PMID: 14367676
-
Studies with radioactive endotoxin. II. Correlation of physiologic effects with distribution of radioactivity in rabbits injected with radioactive sodium chromate.J Clin Invest. 1955 Jun;34(6):858-66 PMID: 14381515
-
The properties and biologic effects of bacterial pyrogens.Medicine (Baltimore). 1950 Dec;29(4):365-400 PMID: 14796349
-
Leukocytic and pyrogenic effects of typhoid vaccine and augmentation by homologous plasma.Proc Soc Exp Biol Med. 1950 Dec;75(3):661-6 PMID: 14808359
-
Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis.J Exp Med. 1951 May;93(5):489-504 PMID: 14832396
-
TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.J Exp Med. 1947 Jun 30;86(1):29-38 PMID: 19871652
-
TOLERANCE TO BACTERIAL PYROGENS : II. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM.J Exp Med. 1947 Jun 30;86(1):39-44 PMID: 19871653
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
