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PMID: 13673086 Published · ppublish English Journal Article

Study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanisms for excretion of urate in man.

The Journal of clinical investigation ·Vol. 38 ·No. 8 ·1959-08-00 ·Pages 1298-315

YU TF, GUTMAN AB

Abstract

暂无摘要

Keywords
KIDNEYS/physiology SALICYLATES/effects URIC ACID/metabolism
MeSH Terms
Biological Transport Body Fluids Humans Kidney/physiology Salicylates/pharmacology Uric Acid/metabolism
Chemicals
Salicylates Uric Acid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
YU T F
GUTMAN A B
References (32)
32 references, click to expand
  1. Gout, a derangement of purine metabolism.
    Adv Intern Med. 1952;5:227-302 PMID: 12996336
  2. Effect of phenylbutazone (3,5 dioxo-1,2-diphenyl-4-n-butylpyrazolidine) on renal clearance of urate and other discrete renal functions in gouty subjects.
    J Clin Invest. 1953 Nov;32(11):1121-32 PMID: 13108975
  3. The kidney.
    Annu Rev Physiol. 1954;16:269-304 PMID: 13171827
  4. Sodium salicylate and probenecid in the treatment of chronic gout; assessment of their relative effects in lowering serum uric acid levels.
    Ann Rheum Dis. 1954 Sep;13(3):233-45 PMID: 13198057
  5. Paradoxical retention of uric acid by uricosuric drugs in low dosage.
    Proc Soc Exp Biol Med. 1955 Nov;90(2):542-7 PMID: 13273509
  6. The excretion of salicylate.
    Br J Pharmacol Chemother. 1955 Dec;10(4):484-9 PMID: 13276608
  7. The effect of salicylic acid and acetylsalicylic acid on uric acid excretion and plasma uric acid concentration in the normal human subject.
    Acta Pharmacol Toxicol (Copenh). 1955;11(4):355-61 PMID: 13301785
  8. Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent.
    J Clin Invest. 1956 Apr;35(4):374-85 PMID: 13306779
  9. A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.
    J Pharmacol Exp Ther. 1957 Mar;119(3):418-26 PMID: 13417097
  10. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout.
    Am J Med. 1957 Oct;23(4):600-22 PMID: 13469831
  11. Effect of pyrazinamide and pyrazinoic acid on urate clearance and other discrete renal functions.
    Proc Soc Exp Biol Med. 1957 Oct;96(1):264-7 PMID: 13485075
  12. Electromigration on filter paper of uric acid from serum and synovial fluid.
    Science. 1958 Jan 10;127(3289):85-6 PMID: 13495485
  13. Evaluation of uricosuric agents in chronic gout.
    Ann Rheum Dis. 1957 Dec;16(4):425-37 PMID: 13498593
  14. Effect of sodium lactate infusion on urate clearance in man.
    Proc Soc Exp Biol Med. 1957 Dec;96(3):809-13 PMID: 13505867
  15. Non-ionic diffusion and the excretion of weak acids and bases.
    Am J Med. 1958 May;24(5):709-29 PMID: 13520769
  16. Renal regulation of uric acid excretion in normal and gouty man; modification by uricosuric agents.
    Bull N Y Acad Med. 1958 May;34(5):287-96 PMID: 13523299
  17. Salicylate and salicyl conjugates: fluorimetric estimation, biosynthesis and renal excretion in man.
    J Clin Invest. 1958 Jun;37(6):800-7 PMID: 13549591
  18. Zoxazolamine: physiological disposition, uricosuric properties.
    Am J Med. 1958 Sep;25(3):401-8 PMID: 13571254
  19. Value of uricosuric agents and in particular of G. 28 315 in gout.
    Ann Rheum Dis. 1958 Sep;17(3):326-33 PMID: 13583918
  20. The diagnosis of gout; significance of an elevated serum uric acid value.
    N Engl J Med. 1958 Dec 4;259(23):1095-9 PMID: 13600630
  21. Results of a clinical trial of G-28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects.
    Arthritis Rheum. 1958 Dec;1(6):532-43 PMID: 13607265
  22. Probenecid and salicylates: the question of interaction in terms of penicillin excretion.
    J Lab Clin Med. 1955 Mar;45(3):478-84 PMID: 14354335
  23. A study, by simultaneous clearance techniques, of salicylate excretion in man: effect of alkalinization of the urine by bicarbonate administration; effect of probenecid.
    J Clin Invest. 1955 May;34(5):711-21 PMID: 14367529
  24. Inhibition of the uricosuric action of benemid by salicylate.
    J Lab Clin Med. 1955 May;45(5):771-7 PMID: 14368045
  25. Thiosulphate clearance in pregnancy.
    J Clin Invest. 1950 Sep;29(9):1207-13 PMID: 14774467
  26. Some recent advances in the study of uric acid metabolism and gout.
    Bull N Y Acad Med. 1951 Mar;27(3):144-64 PMID: 14812253
  27. Benemid (p-di-n-propylsulfamyl)-benzoic acid) as uricosuric agent in chronic gouty arthritis.
    Trans Assoc Am Physicians. 1951;64:279-88 PMID: 14884260
  28. Therapeutic value of probenecid (benemid) in gout.
    J Am Med Assoc. 1952 Jul 26;149(13):1188-94 PMID: 14938138
  29. Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects.
    J Clin Invest. 1952 Jul;31(7):692-701 PMID: 14938444
  30. The influence of urinary pH on the renal excretion of salicyl derivatives during aspirin therapy.
    J Lab Clin Med. 1950 Feb;35(2):237-48 PMID: 15404238
  31. The renal mechanism for urate excretion in man.
    J Clin Invest. 1950 Apr;29(4):396-401 PMID: 15415439
  32. THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN.
    J Clin Invest. 1945 May;24(3):388-404 PMID: 16695228
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI103905
Published
1959-08-00
Pages
1298-315
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC442084
Subset
OM
External Links
PubMed source DOI: 10.1172/JCI103905 PMC Full Text View journal details
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