Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent.

The Journal of clinical investigation ·Vol. 35 ·No. 4 ·1956-04-00 ·Pages 374-85

YU TF, PATON BC, CHENKIN T, BURNS JJ, BRODIE BB, GUTMAN AB

Abstract

暂无摘要

Keywords

GOUT/therapy KIDNEYS/effect of drugs on

MeSH Terms

Biphenyl Compounds Gout/therapy Humans Kidney/drug effects Phenylbutazone Pyrazoles Uric Acid Uricosuric Agents

Chemicals

Biphenyl Compounds Pyrazoles Uricosuric Agents Uric Acid diphenyl pyrazole Phenylbutazone

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

YU T F

PATON B C

CHENKIN T

BURNS J J

BRODIE B B

GUTMAN A B

References (11)

11 references, click to expand

The effect of phenylbutazone on uric acid metabolism in two normal subjects.
J Clin Invest. 1955 Feb;34(2):256-62 PMID: 13233347
Further observation on the uricosuric effects of probenecid (benemid) in tophaceous gout.
Trans Assoc Am Physicians. 1954;67:250-60 PMID: 13216834
The metabolic fate of phenylbutazone (butazolidin) in man.
J Pharmacol Exp Ther. 1955 Apr;113(4):481-9 PMID: 14368518
Observations on G-25671, a phenylbutazone analogue (4-phenylthioethyl)-1,2-diphenyl 3,5-pyrazolidinedione).
Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):884-7 PMID: 13204385
Phenylbutazone (butazolidin) in gout.
Am J Med. 1954 Feb;16(2):212-7 PMID: 13124352
Effect of phenylbutazone (3,5 dioxo-1,2-diphenyl-4-n-butylpyrazolidine) on renal clearance of urate and other discrete renal functions in gouty subjects.
J Clin Invest. 1953 Nov;32(11):1121-32 PMID: 13108975
Current principles of management in gout.
Am J Med. 1952 Dec;13(6):744-59 PMID: 13016572
Paradoxical retention of uric acid by uricosuric drugs in low dosage.
Proc Soc Exp Biol Med. 1955 Nov;90(2):542-7 PMID: 13273509
Ultrafiltrability of plasma urate in man.
Proc Soc Exp Biol Med. 1953 Oct;84(1):21-4 PMID: 13120923
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.
J Pharmacol Exp Ther. 1953 Nov;109(3):346-57 PMID: 13109696
Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects.
J Clin Invest. 1952 Jul;31(7):692-701 PMID: 14938444

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI103288

Published

1956-04-00

Pages

374-85

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC438822

Subset

External Links

PubMed source DOI: 10.1172/JCI103288 PMC Full Text View journal details

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Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent.

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