Studies on the Cx-reactive protein. I. The effect of administration of Cx-reactive protein to normal rabbits.

It has been found that normal rabbits respond to the intravenous administration of Cx-reactive protein by producing this acute phase substance. When Cx-reactive protein incorporated in adjuvant is injected intracutaneously, in addition to producing Cx-reactive protein, the recipient animals develop a characteristic inflammatory reaction about the site of injection. This inflammatory reaction can be inhibited by the prior intravenous injection of thorotrast.