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PMID: 1329725 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.

The Biochemical journal ·Vol. 287 ( Pt 1) ·1992-10-01 ·Pages 17-20

Gaussin V, Baquet A, Hue L

Abstract

The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.

MeSH Terms
Animals Cell Size/drug effects Cyclic AMP/metabolism Glucagon/pharmacology Gluconeogenesis/drug effects In Vitro Techniques Insulin/pharmacology Liver/cytology,metabolism Liver Glycogen/metabolism Male Phosphorylases/metabolism Pyruvate Kinase/metabolism Rats Rats, Wistar Water-Electrolyte Balance/drug effects
Chemicals
Insulin Liver Glycogen Glucagon Cyclic AMP Phosphorylases Pyruvate Kinase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gaussin V
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.
Baquet A
Hue L
References (23)
23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2870017
Published
1992-10-01
Pages
17-20
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1133117
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2870017 PMC Full Text View journal details
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