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PMID: 1680322 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase.

The Biochemical journal ·Vol. 278 ( Pt 3) ·1991-09-15 ·Pages 887-90

Baquet A, Maisin L, Hue L

Abstract

Incubation of hepatocytes in conditions known to increase their volume, i.e. with amino acids or in hypo-osmotic media, resulted in the parallel activation of glycogen synthase and acetyl-CoA carboxylase. The activation of both enzymes by glutamine was antagonized by the addition of raffinose to prevent cell swelling, or by glucagon and microcystin. The findings are consistent with the involvement of a common mechanism for the activation of the two enzymes.

MeSH Terms
Acetyl-CoA Carboxylase/metabolism Amino Acids/pharmacology Animals Enzyme Activation/drug effects Glucagon/pharmacology Glutamine/pharmacology Glycogen Synthase/metabolism Kinetics Liver/cytology,drug effects,enzymology Male Marine Toxins Microcystins Osmolar Concentration Peptides, Cyclic/pharmacology Proline/pharmacology Raffinose/pharmacology Rats Rats, Inbred Strains
Chemicals
Amino Acids Marine Toxins Microcystins Peptides, Cyclic Glutamine Glucagon Proline Glycogen Synthase Acetyl-CoA Carboxylase cyanoginosin LR Raffinose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Baquet A
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.
Maisin L
Hue L
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2780887
Published
1991-09-15
Pages
887-90
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1151430
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2780887 PMC Full Text View journal details
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