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PMID: 1315333 Published · ppublish English Journal Article

Distribution of serotypes of human rotavirus in different populations.

Journal of clinical microbiology ·Vol. 30 ·No. 4 ·1992-04-00 ·Pages 781-5

Woods PA, Gentsch J, Gouvea V, Mata L, Santosham M, Bai ZS, Urasawa S, Glass RI

Abstract

Serotyping is a useful tool to study the epidemiologic characteristics of rotaviruses in large populations and to assess the need for a vaccine to protect against all strains. By using an enzyme immunoassay with serotype-specific monoclonal antibodies to the four most common rotavirus serotypes, we analyzed 1,183 rotavirus-positive specimens from 16 stool collections in eight countries on four continents that were obtained from 1978 to 1989. Of the 926 strains (78%) that could be serotyped, 48% were serotype 1, 8% were serotype 2, 15% were serotype 3, and 7% were serotype 4. Twenty-two percent had insufficient numbers of double-shelled virus particles to react with the monoclonal antibody of the VP4 rotavirus protein and therefore could not be serotyped. Our results indicate that vaccines being developed must provide the greatest coverage against serotype 1 and that the serotype distribution cannot be predicted currently by the geographic area or prevalence in the preceding year.

MeSH Terms
Antibodies, Monoclonal Humans Immunoenzyme Techniques Rotavirus/classification,immunology Rotavirus Infections/epidemiology,microbiology Seroepidemiologic Studies Serotyping
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Woods P A
Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Gentsch J
Gouvea V
Mata L
Santosham M
Bai Z S
Urasawa S
Glass R I
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.30.4.781-785.1992
Published
1992-04-00
Pages
781-5
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC265161
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.30.4.781-785.1992 PMC Full Text View journal details
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