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PMID: 1309254 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The fibroblast growth factor receptor is not required for herpes simplex virus type 1 infection.

Journal of virology ·Vol. 66 ·No. 1 ·1992-01-00 ·Pages 448-57

Mirda DP, Navarro D, Paz P, Lee PL, Pereira L, Williams LT

Abstract

The early events mediating herpes simplex virus type 1 (HSV-1) infection include virion attachment to cell surface heparan sulfates and subsequent penetration. Recent evidence has suggested that the high-affinity fibroblast growth factor (FGF) receptor mediates HSV-1 entry. This report presents three lines of experimental evidence showing that the high-affinity FGF receptor is not required for HSV-1 infection. First, rat L6 myoblasts lacking FGF receptors were as susceptible to HSV-1 infection as L6 cells genetically engineered to express the FGF receptor. Second, a soluble FGF receptor fragment that inhibited FGF binding and receptor activation did not inhibit HSV-1 infection. Finally, basic FGF (but not acidic FGF) inhibited HSV-1 infection in L6 cells lacking FGF receptors, presumably by blocking cell surface heparan sulfates also required for HSV-1 infection. These results show that the high-affinity FGF receptor is not required for HSV-1 infection but instead that specific low-affinity basic FGF binding sites are used for HSV-1 infection.

MeSH Terms
Animals Cell Line Fibroblast Growth Factors/metabolism Fluorescent Antibody Technique Rats Receptors, Cell Surface/genetics,metabolism Receptors, Fibroblast Growth Factor Simplexvirus/metabolism,physiology Solubility Transfection Vero Cells Virus Replication
Chemicals
Receptors, Cell Surface Receptors, Fibroblast Growth Factor Fibroblast Growth Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mirda D P
Cancer Research Institute, University of California, San Francisco 94143-0724.
Navarro D
Paz P
Lee P L
Pereira L
Williams L T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.1.448-457.1992
Published
1992-01-00
Pages
448-57
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC238305
Subset
IM
Grants
NIAID NIH HHS · AI-23592 · United States
NIAID NIH HHS · AI-30873 · United States
NHLBI NIH HHS · HL-43821 · United States
External Links
PubMed source DOI: 10.1128/JVI.66.1.448-457.1992 PMC Full Text View journal details
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