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PMID: 12631384 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Is there a role for Notch signalling in human breast cancer?

Breast cancer research : BCR ·Vol. 5 ·No. 2 ·2003-00-00 ·Pages 69-75

Brennan K, Brown AM

Abstract

Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.

MeSH Terms
Breast Neoplasms/physiopathology Female Humans Membrane Proteins/physiology Receptors, Notch Signal Transduction
Chemicals
Membrane Proteins Receptors, Notch
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brennan Keith
School of Biological Sciences, University of Manchester, UK. keith.brennan@man.ac.uk
Brown Anthony M C
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Article Info
Journal
Breast cancer research : BCR
Abbr.
Breast Cancer Res
ISSN
1465-542X
DOI
10.1186/bcr559
Email
keith.brennan@man.ac.uk
Published
2003-00-00
Epub
2003-00-20
Pages
69-75
Language
English
Region
England
NLM ID
100927353
PMCID
PMC154142
Subset
IM
Grants
Breast Cancer Now · 2001:245 · United Kingdom
NCI NIH HHS · R01 CA047207 · United States
External Links
PubMed source DOI: 10.1186/bcr559 PMC Full Text View journal details
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