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PMID: 10837024 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Dll4, a novel Notch ligand expressed in arterial endothelium.

Genes & development ·Vol. 14 ·No. 11 ·2000-06-01 ·Pages 1313-8

Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL

Abstract

We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.

MeSH Terms
Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Arteries/metabolism Base Sequence Blotting, Northern Calcium-Binding Proteins Chromosome Mapping Chromosomes, Human, Pair 15 Cloning, Molecular DNA, Complementary/metabolism Endothelium, Vascular/metabolism Humans In Situ Hybridization Intracellular Signaling Peptides and Proteins/chemistry,genetics,metabolism Ligands Membrane Proteins/biosynthesis,chemistry,genetics,metabolism Mice Molecular Sequence Data Protein Binding Proto-Oncogene Proteins/metabolism Receptor, Notch1 Receptor, Notch4 Receptors, Cell Surface Receptors, Notch Sequence Homology, Amino Acid Tissue Distribution Transcription Factors Xenopus
Chemicals
Adaptor Proteins, Signal Transducing Calcium-Binding Proteins DLL4 protein, mouse DNA, Complementary Intracellular Signaling Peptides and Proteins Ligands Membrane Proteins NOTCH1 protein, human NOTCH4 protein, human Notch1 protein, mouse Proto-Oncogene Proteins Receptor, Notch1 Receptor, Notch4 Receptors, Cell Surface Receptors, Notch Transcription Factors delta protein
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Shutter J R
Departments of Molecular Genetics, Amgen, Inc., Thousand Oaks, California 91320 USA.
Scully S
Fan W
Richards W G
Kitajewski J
Deblandre G A
Kintner C R
Stark K L
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
Published
2000-06-01
Pages
1313-8
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC316657
Subset
IM
Grants
NHLBI NIH HHS · R01 HL062454 · United States
NHLBI NIH HHS · HL62454 · United States
External Links
PubMed source PMC Full Text View journal details
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