Home LiteratureArticle Details
PMID: 12370266 Published · ppublish English Journal Article Review

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

The Journal of clinical investigation ·Vol. 110 ·No. 7 ·2002-10-00 ·Pages 905-11

Tabas I

Abstract

暂无摘要

MeSH Terms
Adaptation, Physiological Animals Arteriosclerosis/etiology Cell Death Cholesterol/metabolism,toxicity Humans Macrophages/metabolism
Chemicals
Cholesterol
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tabas Ira
Department of Medicine, Columbia University, New York, New York 10032, USA. iat1@columbia.edu
References (46)
46 references, click to expand
  1. Do oxysterols control cholesterol homeostasis?
    J Clin Invest. 2002 Sep;110(6):725-30 PMID: 12235099
  2. Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.
    Biochemistry. 1998 Dec 8;37(49):17299-308 PMID: 9860844
  3. Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.
    J Biol Chem. 2000 Aug 4;275(31):23807-13 PMID: 10791964
  4. Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.
    J Clin Invest. 1976 Jul;58(1):200-11 PMID: 932206
  5. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.
    J Lipid Res. 1993 Oct;34(10):1637-59 PMID: 8245716
  6. ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
    J Biol Chem. 2002 Nov 8;277(45):43271-80 PMID: 12215451
  7. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
    Nat Med. 2000 Dec;6(12):1341-7 PMID: 11100118
  8. Therapies on the horizon for cholesterol reduction.
    Clin Cardiol. 2001 Aug;24(8 Suppl):III24-7 PMID: 11501600
  9. Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions.
    Trends Cardiovasc Med. 1997 Oct;7(7):256-63 PMID: 21235894
  10. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
    J Clin Invest. 2001 Jan;107(2):163-71 PMID: 11160132
  11. Regulation and mechanisms of macrophage cholesterol efflux.
    J Clin Invest. 2002 Oct;110(7):899-904 PMID: 12370265
  12. Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells.
    J Biol Chem. 1993 May 5;268(13):9653-60 PMID: 8486653
  13. Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester.
    Lab Invest. 1979 Aug;41(2):160-7 PMID: 459432
  14. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
    Nat Cell Biol. 2001 Oct;3(10):905-12 PMID: 11584272
  15. Modulation of membrane function by cholesterol.
    Biochimie. 1991 Oct;73(10):1303-10 PMID: 1664240
  16. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. A cytochemical and ultrastructural study.
    Atherosclerosis. 1987 Oct;67(2-3):127-42 PMID: 2445362
  17. Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway.
    J Biol Chem. 2001 Nov 9;276(45):42468-76 PMID: 11533046
  18. Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.
    Curr Opin Lipidol. 2001 Jun;12(3):289-96 PMID: 11353332
  19. Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum.
    J Lipid Res. 2001 Nov;42(11):1771-81 PMID: 11714846
  20. Cell biology of atherosclerosis.
    Annu Rev Physiol. 1995;57:791-804 PMID: 7778883
  21. Atherosclerosis. the road ahead.
    Cell. 2001 Feb 23;104(4):503-16 PMID: 11239408
  22. How cells handle cholesterol.
    Science. 2000 Dec 1;290(5497):1721-6 PMID: 11099405
  23. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
    J Clin Invest. 2002 May;109(9):1125-31 PMID: 11994399
  24. Cholesterol, lipid rafts, and disease.
    J Clin Invest. 2002 Sep;110(5):597-603 PMID: 12208858
  25. Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells.
    J Biol Chem. 2000 Dec 1;275(48):38104-10 PMID: 10978332
  26. Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death.
    Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):423-31 PMID: 9514411
  27. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.
    Science. 1995 Mar 24;267(5205):1828-31 PMID: 7892608
  28. Cell death in atherosclerotic plaques.
    Curr Opin Lipidol. 1996 Oct;7(5):324-9 PMID: 8937524
  29. Crystallization of free cholesterol in model macrophage foam cells.
    Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1891-8 PMID: 10446067
  30. Intracellular cholesterol transport.
    Biochim Biophys Acta. 1999 Apr 19;1438(1):19-37 PMID: 10216277
  31. Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol.
    J Biol Chem. 1995 Mar 17;270(11):5772-8 PMID: 7890706
  32. Cholesterol and phospholipid metabolism in macrophages.
    Biochim Biophys Acta. 2000 Dec 15;1529(1-3):164-74 PMID: 11111086
  33. Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis.
    J Biol Chem. 1996 Sep 13;271(37):22773-81 PMID: 8798453
  34. Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response.
    J Biol Chem. 2000 Nov 10;275(45):35368-76 PMID: 10944538
  35. Cholesterol in health and disease.
    J Clin Invest. 2002 Sep;110(5):583-90 PMID: 12208856
  36. Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis.
    J Cell Physiol. 2000 Jan;182(1):41-9 PMID: 10567915
  37. The origin of aortic phospholipid in rabbit atheromatosis.
    Circulation. 1954 Apr;9(4):581-5 PMID: 13150523
  38. Oxysterols and atherosclerosis.
    Atherosclerosis. 1999 Jan;142(1):1-28 PMID: 9920502
  39. Intracellular cholesterol transport.
    J Clin Invest. 2002 Oct;110(7):891-8 PMID: 12370264
  40. Cholesterol is not crucial for the existence of microdomains in kidney brush-border membrane models.
    J Biol Chem. 2002 Jan 11;277(2):875-8 PMID: 11717303
  41. Acyl-coenzyme A:cholesterol acyltransferase.
    Annu Rev Biochem. 1997;66:613-38 PMID: 9242919
  42. Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects.
    Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1519-22 PMID: 9763521
  43. ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells.
    Biochem Soc Trans. 1998 Nov;26(4):629-35 PMID: 10047795
  44. Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
    J Biol Chem. 2001 Nov 30;276(48):44976-83 PMID: 11579092
  45. Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
    Arterioscler Thromb Vasc Biol. 1995 Sep;15(9):1378-87 PMID: 7670952
  46. Mass spectrometric analysis reveals an increase in plasma membrane polyunsaturated phospholipid species upon cellular cholesterol loading.
    Biochemistry. 2001 Dec 4;40(48):14635-44 PMID: 11724577
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI16452
Email
iat1@columbia.edu
Published
2002-10-00
Pages
905-11
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC151158
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI16452 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2